dc.contributor.author | Aktoz, Tevfik | |
dc.contributor.author | Kanter, Mehmet | |
dc.contributor.author | Uz, Yesim Hulya | |
dc.contributor.author | Aktaş, Cevat | |
dc.contributor.author | Erboğa, Mustafa | |
dc.contributor.author | Atakan, İrfan Hüseyin | |
dc.date.accessioned | 2022-05-11T14:41:26Z | |
dc.date.available | 2022-05-11T14:41:26Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 2146-3123 | |
dc.identifier.issn | 2146-3131 | |
dc.identifier.uri | https://doi.org/10.5152/balkanmedj.2011.014 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9179 | |
dc.description.abstract | Objective: The aim of the present study was to examine the protective effect of quercetine (QE) against cadmium (Cd)-induced renal toxicity. Material and Methods: A total of 24 male Wistar albino rats were divided into three groups: control, Cd-treated and Cd-treated with QE; each group containing 8 animals. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in the QE treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection during the study period. Results: The renal histology in Cd-treated rats showed mesangial expansion, thickening of capsular basement membranes, glomerular basement membranes and tubular basement membranes, characterized by an increase in periodic acid Schiff (PAS)-positive areas as compared with control animals. With the QE treatment, despite the presence of only a few swollen glomeruli, we noticed a marked protection of renal structure when compared with the Cd-treated rats. Furthermore, QE pretreatment resulted in increased proliferating cell nuclear antigen (PCNA) immunoreactivity and decreased the activity of Terminal Transferase dUTP Nick End Labeling (TUNEL). Conclusion: These findings suggest that QE may attenuate Cd-induced renal toxicity. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Galenos Publ House | en_US |
dc.identifier.doi | 10.5152/balkanmedj.2011.014 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cadmium | en_US |
dc.subject | immunohistochemistry | en_US |
dc.subject | quercetin | en_US |
dc.subject | renal toxicity | en_US |
dc.subject | TUNEL | en_US |
dc.subject | Lipid-Peroxidation | en_US |
dc.subject | Ultrastructural-Changes | en_US |
dc.subject | Cell-Death | en_US |
dc.subject | Kidney | en_US |
dc.subject | Nephrotoxicity | en_US |
dc.subject | Intoxication | en_US |
dc.subject | Exposure | en_US |
dc.subject | Selenium | en_US |
dc.subject | Metallothionein | en_US |
dc.subject | Regeneration | en_US |
dc.title | Protective Effect of Quercetin Against Renal Toxicity Induced by Cadmium in Rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Balkan Medical Journal | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 56 | en_US |
dc.identifier.endpage | 61 | en_US |
dc.institutionauthor | Aktaş, Cevat | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 13609545500 | |
dc.authorscopusid | 7006356462 | |
dc.authorscopusid | 8583021500 | |
dc.authorscopusid | 24436194200 | |
dc.authorscopusid | 36023238400 | |
dc.authorscopusid | 7801455897 | |
dc.authorwosid | Aktas, Cevat/D-8468-2011 | |
dc.identifier.wos | WOS:000303618400011 | en_US |
dc.identifier.scopus | 2-s2.0-84862067233 | en_US |