dc.contributor.author | Balkan, İlker İnanç | |
dc.contributor.author | Batırel, Ayşe | |
dc.contributor.author | Karabay, Oğuz | |
dc.contributor.author | Ağalar, Canan | |
dc.contributor.author | Akalın, Şerife | |
dc.contributor.author | Alici, Özlem | |
dc.contributor.author | Yılmaz, Hava | |
dc.contributor.author | Doğan, Mustafa | |
dc.date.accessioned | 2022-05-11T14:37:23Z | |
dc.date.available | 2022-05-11T14:37:23Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0253-7613 | |
dc.identifier.issn | 1998-3751 | |
dc.identifier.uri | https://doi.org/10.4103/0253-7613.150383 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/8673 | |
dc.description.abstract | Objectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.identifier.doi | 10.4103/0253-7613.150383 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Blood stream infection | en_US |
dc.subject | colistin | en_US |
dc.subject | monotherapy | en_US |
dc.subject | multi drug resistant Acinetobacter spp | en_US |
dc.subject | Gram-Negative Bacteria | en_US |
dc.subject | Critically-Ill Patients | en_US |
dc.subject | Baumannii Bacteremia | en_US |
dc.subject | Risk-Factors | en_US |
dc.subject | Antimicrobial Therapy | en_US |
dc.subject | Mortality | en_US |
dc.subject | Outcomes | en_US |
dc.subject | Impact | en_US |
dc.subject | Appropriate | en_US |
dc.subject | Sulbactam | en_US |
dc.title | Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Indian Journal of Pharmacology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-7149-2968 | |
dc.authorid | 0000-0002-1104-8232 | |
dc.authorid | 0000-0002-8977-5931 | |
dc.authorid | 0000-0002-0244-4006 | |
dc.authorid | 0000-0003-1514-1685 | |
dc.authorid | 0000-0003-0502-432X | |
dc.authorid | 0000-0002-4034-9202 | |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 95 | en_US |
dc.identifier.endpage | 100 | en_US |
dc.institutionauthor | Doğan, Mustafa | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57211248494 | |
dc.authorscopusid | 6505508467 | |
dc.authorscopusid | 23060531400 | |
dc.authorscopusid | 56029680900 | |
dc.authorscopusid | 7004827493 | |
dc.authorscopusid | 23494580100 | |
dc.authorscopusid | 8726721500 | |
dc.authorwosid | ARSLAN, FERHAT/ABG-5757-2021 | |
dc.authorwosid | Oztoprak, Nefise/AAD-2679-2019 | |
dc.authorwosid | Hatipoğlu, Çiğdem Ataman/AAA-4135-2021 | |
dc.authorwosid | altay, fatma aybala/AFP-3599-2022 | |
dc.authorwosid | balkan, ilker inanc/AAI-1578-2019 | |
dc.authorwosid | Örmen, Bahar/ABA-1027-2021 | |
dc.authorwosid | Kilic, Aysegul Ulu/AAM-1069-2021 | |
dc.identifier.wos | WOS:000349144300018 | en_US |
dc.identifier.scopus | 2-s2.0-84923055629 | en_US |
dc.identifier.pmid | 25821319 | en_US |