dc.contributor.author | Ünal, F. | |
dc.contributor.author | Yüksel, M. Aytaç | |
dc.contributor.author | Boran, Birtan | |
dc.contributor.author | Yüksel, I. Temel | |
dc.contributor.author | Abalı, Remzi | |
dc.date.accessioned | 2022-05-11T14:35:46Z | |
dc.date.available | 2022-05-11T14:35:46Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0144-3615 | |
dc.identifier.issn | 1364-6893 | |
dc.identifier.uri | https://doi.org/10.3109/01443615.2015.1065236 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/8214 | |
dc.description.abstract | This study assessed whether NAC could prevent cyclophosphamide (CY)-induced damage, by measuring the anti-Mullerian hormone (AMH) levels. Forty-eight Sprague-Dawley female rats were divided into four groups: CY + NAC, CY, NAC and control, each including 12 rats. There was no significant difference among the 24-h AMH values of the groups (p = 0.452), whereas a significant difference was found in terms of 72-h values (p = 0.003). Paired comparisons revealed no significant difference between CY and CY + NAC (p>0.699) and NAC (p = 0.065) groups regarding 72-h AMH values. However, AMH concentrations of the CY group at 72 hours were significantly lower than those of the control group (p = 0.015). AMH concentrations of the CY + NAC group at 72 hours were also significantly lower than those of the NAC group (p = 0.002) and the control group (p = 0.002). The AMH levels of CY and CY + NAC groups at 72 hours were significantly lower than those at 24 hours. The 24-h and 72-h AMH levels in the NAC and control groups were similar. In the present study, a single dose of NAC failed to prevent the cytotoxic effects of CY. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Inc | en_US |
dc.identifier.doi | 10.3109/01443615.2015.1065236 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | gonadotoxicity | en_US |
dc.subject | cyclophosphamide | en_US |
dc.subject | anti-Mullerian hormone | en_US |
dc.subject | N-Acetylcysteine | en_US |
dc.subject | Follicle-Stimulating-Hormone | en_US |
dc.subject | Anti-Mullerian Hormone | en_US |
dc.subject | Ovarian Reserve | en_US |
dc.subject | Fertility Preservation | en_US |
dc.subject | Buthionine Sulfoximine | en_US |
dc.subject | Glutathione Depletion | en_US |
dc.subject | Induced Apoptosis | en_US |
dc.subject | Cancer-Patients | en_US |
dc.subject | Chemotherapy | en_US |
dc.subject | Cysteine | en_US |
dc.title | The role of N-Acetylcysteine in preventing cyclophosphamide-induced gonadotoxicity: An experimental study in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Obstetrics and Gynaecology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-8182-2051 | |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 372 | en_US |
dc.identifier.endpage | 375 | en_US |
dc.institutionauthor | Abalı, Remzi | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 43262210900 | |
dc.authorscopusid | 41862830000 | |
dc.authorscopusid | 7801342819 | |
dc.authorscopusid | 56921678300 | |
dc.authorscopusid | 6506061779 | |
dc.identifier.wos | WOS:000373739200024 | en_US |
dc.identifier.scopus | 2-s2.0-84945218403 | en_US |
dc.identifier.pmid | 26466512 | en_US |