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dc.contributor.authorÜnal, F.
dc.contributor.authorYüksel, M. Aytaç
dc.contributor.authorBoran, Birtan
dc.contributor.authorYüksel, I. Temel
dc.contributor.authorAbalı, Remzi
dc.date.accessioned2022-05-11T14:35:46Z
dc.date.available2022-05-11T14:35:46Z
dc.date.issued2016
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.urihttps://doi.org/10.3109/01443615.2015.1065236
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8214
dc.description.abstractThis study assessed whether NAC could prevent cyclophosphamide (CY)-induced damage, by measuring the anti-Mullerian hormone (AMH) levels. Forty-eight Sprague-Dawley female rats were divided into four groups: CY + NAC, CY, NAC and control, each including 12 rats. There was no significant difference among the 24-h AMH values of the groups (p = 0.452), whereas a significant difference was found in terms of 72-h values (p = 0.003). Paired comparisons revealed no significant difference between CY and CY + NAC (p>0.699) and NAC (p = 0.065) groups regarding 72-h AMH values. However, AMH concentrations of the CY group at 72 hours were significantly lower than those of the control group (p = 0.015). AMH concentrations of the CY + NAC group at 72 hours were also significantly lower than those of the NAC group (p = 0.002) and the control group (p = 0.002). The AMH levels of CY and CY + NAC groups at 72 hours were significantly lower than those at 24 hours. The 24-h and 72-h AMH levels in the NAC and control groups were similar. In the present study, a single dose of NAC failed to prevent the cytotoxic effects of CY.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Incen_US
dc.identifier.doi10.3109/01443615.2015.1065236
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgonadotoxicityen_US
dc.subjectcyclophosphamideen_US
dc.subjectanti-Mullerian hormoneen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectFollicle-Stimulating-Hormoneen_US
dc.subjectAnti-Mullerian Hormoneen_US
dc.subjectOvarian Reserveen_US
dc.subjectFertility Preservationen_US
dc.subjectButhionine Sulfoximineen_US
dc.subjectGlutathione Depletionen_US
dc.subjectInduced Apoptosisen_US
dc.subjectCancer-Patientsen_US
dc.subjectChemotherapyen_US
dc.subjectCysteineen_US
dc.titleThe role of N-Acetylcysteine in preventing cyclophosphamide-induced gonadotoxicity: An experimental study in ratsen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-8182-2051
dc.identifier.volume36en_US
dc.identifier.issue3en_US
dc.identifier.startpage372en_US
dc.identifier.endpage375en_US
dc.institutionauthorAbalı, Remzi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid43262210900
dc.authorscopusid41862830000
dc.authorscopusid7801342819
dc.authorscopusid56921678300
dc.authorscopusid6506061779
dc.identifier.wosWOS:000373739200024en_US
dc.identifier.scopus2-s2.0-84945218403en_US
dc.identifier.pmid26466512en_US


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