dc.contributor.author | Cengiz, N. | |
dc.date.accessioned | 2022-05-11T14:31:04Z | |
dc.date.available | 2022-05-11T14:31:04Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0014-3057 | |
dc.identifier.uri | https://doi.org/10.1016/j.eurpolymj.2019.109441 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/7301 | |
dc.description.abstract | A novel glutathione-responsive hydrogel was synthesized through catalyst-free epoxy-amine ‘click’ chemistry using PEG-diamine and a redox-responsive diepoxy crosslinker. The chain length of PEG-diamine component was varied to modulate the physical characteristics of thus obtained hydrogels. Hydrogels exhibited degradation upon treatment with glutathione, as evident through visually apparanet gel disolution and rheological measurements. The unreacted epoxy and newly formed hydroxyl groups post-gelation were used as reactive handles to functionalize the hydrogels, as demonstrated through attachment of different fluorescent probes. Finally, it was also established that these hydrogels provide an efficient platform for ligand-directed biomolecular immobilization through anchoring of a fluorescently labelled protein onto the hydrogels. © 2019 Elsevier Ltd | en_US |
dc.description.sponsorship | 115Z661; AR.15.02; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK | en_US |
dc.description.sponsorship | This work is supported by the Scientific and Technological Research Council of Turkey (TUBITAK Project No. 115Z661). The author thanks the Center for Life Sciences and Technologies at Bogazici University for help with analysis and characterization. The author also thanks Tekirdag Namik Kemal University Scientific Research Projects Fund (Project No. NKUBAP.00.10.AR.15.02). | en_US |
dc.description.sponsorship | This work is supported by the Scientific and Technological Research Council of Turkey (TUBITAK Project No. 115Z661 ). The author thanks the Center for Life Sciences and Technologies at Bogazici University for help with analysis and characterization. The author also thanks Tekirdag Namik Kemal University Scientific Research Projects Fund (Project No. NKUBAP.00.10.AR.15.02 ). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.identifier.doi | 10.1016/j.eurpolymj.2019.109441 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Epoxy-amine click | en_US |
dc.subject | Glutathione | en_US |
dc.subject | Hydrogel | en_US |
dc.subject | Redox-responsive | en_US |
dc.subject | Amines | en_US |
dc.subject | Gelation | en_US |
dc.subject | Peptides | en_US |
dc.subject | Biomolecular immobilization | en_US |
dc.subject | Epoxy amine | en_US |
dc.subject | Fluorescent probes | en_US |
dc.subject | Glutathiones | en_US |
dc.subject | Physical characteristics | en_US |
dc.subject | Redox-responsive | en_US |
dc.subject | Responsive hydrogels | en_US |
dc.subject | Rheological measurements | en_US |
dc.subject | Hydrogels | en_US |
dc.title | Glutathione-responsive multifunctionalizable hydrogels via amine-epoxy "click" chemistry | en_US |
dc.type | article | en_US |
dc.relation.ispartof | European Polymer Journal | en_US |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.identifier.volume | 123 | en_US |
dc.institutionauthor | Cengiz, N. | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 36463173500 | |
dc.identifier.scopus | 2-s2.0-85076513213 | en_US |