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Multispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivative

dc.contributor.authorÖzkan, Şule
dc.contributor.authorTaşkın Tok, Tuğba
dc.contributor.authorUzgören Baran, Ayşe
dc.contributor.authorAkbay, Nuriye
dc.date.accessioned2022-05-11T14:31:01Z
dc.date.available2022-05-11T14:31:01Z
dc.date.issued2019
dc.identifier.issn1053-0509
dc.identifier.issn1573-4994
dc.identifier.urihttps://doi.org/10.1007/s10895-018-2314-4
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7284
dc.description.abstractMode of interaction of a new tetrahydrocarbazole derivative with ct-DNA has been investigated systematically using fluorescence spectroscopy, UV-Vis spectroscopy and circular dichroism spectroscopy. It is concluded that TAH could intercalate into the base pairs of ct-DNA, and the fluorescence quenching by ct-DNA was static quenching type. Beside the multispectroscopic results, computational studies were done. Molecular docking results revealed that the TAH-DNAs complexes might be classified as druggable molecule in drug design. Additionally, DNA binding studies exhibited that TAH complexes have different interaction and orientation abilities to each DNA isomer. Combination of experimental and computational data showed that reported TAH is promising structure and deserves further applications.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z391]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) - Grant No 114Z391.en_US
dc.language.isoengen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.identifier.doi10.1007/s10895-018-2314-4
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluorescenceen_US
dc.subjectct-DNAen_US
dc.subjectTetrahydrocabazolesen_US
dc.subjectStern-Volmeren_US
dc.subjectGroove bindingen_US
dc.subjectFluorescent-Probeen_US
dc.subjectGroove Bindingen_US
dc.subjectDesignen_US
dc.subjectAnalogen_US
dc.titleMultispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivativeen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Fluorescenceen_US
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.authorid0000-0003-1405-2920
dc.authorid0000-0002-0064-8400
dc.authorid0000-0002-0064-8400
dc.identifier.volume29en_US
dc.identifier.issue1en_US
dc.identifier.startpage101en_US
dc.identifier.endpage110en_US
dc.institutionauthorÖzkan, Şule
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57204525185
dc.authorscopusid56268532500
dc.authorscopusid36085857200
dc.authorscopusid25630447400
dc.authorwosidUZGÖREN-BARAN, AYŞE/G-9260-2013
dc.authorwosidTASKIN TOK, Tugba/A-8885-2016
dc.authorwosidTok, Tugba Taskin/M-5740-2019
dc.identifier.wosWOS:000462475000010en_US
dc.identifier.scopus2-s2.0-85055929660en_US
dc.identifier.pmid30361860en_US


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