dc.contributor.author | Kandemir, Hakan | |
dc.contributor.author | Ma, Cong | |
dc.contributor.author | Kutty, Samuel K. | |
dc.contributor.author | Black, David StC. | |
dc.contributor.author | Griffith, Renate | |
dc.contributor.author | Lewis, Peter J. | |
dc.contributor.author | Kumar, Naresh | |
dc.date.accessioned | 2022-05-11T14:29:56Z | |
dc.date.available | 2022-05-11T14:29:56Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.issn | 1464-3391 | |
dc.identifier.uri | https://doi.org/10.1016/j.bmc.2014.01.025 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/7179 | |
dc.description.abstract | A range of novel hydrazine bridged bis-indoles was prepared from readily available indole-7-glyoxyloylchlorides and 7-trichloroacetylindoles and underwent cyclodehydration to produce 2,5-di(7-indolyl)-1,3,4-oxadiazoles and a 2,2'-bi-1,3,4-oxadiazolyl with phosphoryl chloride in ethyl acetate. This efficient protocol was subsequently used for the synthesis of 2-and 7-indolyl 2-(1,3,4-thiadiazolyl) ketones from related indolyl-hydrazine carbothioamides. The synthesised bis-indoles were evaluated for their antimicrobial properties, particularly the inhibition of protein-protein complex formation between RNA polymerase andrfactor and their bactericidal effect on Gram positive Bacillus subtilis and Gram negative Escherichia coli. (C) 2014 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | University of New South Wales; Turkish GovernmentTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); NHMRCNational Health and Medical Research Council of Australia [APP1008014] | en_US |
dc.description.sponsorship | We thank the University of New South Wales and the Turkish Government for their financial support. This work was supported with funding from the NHMRC (APP1008014). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
dc.identifier.doi | 10.1016/j.bmc.2014.01.025 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Bis-indoles | en_US |
dc.subject | Oxadiazoles | en_US |
dc.subject | Thiadiazoles | en_US |
dc.subject | Indole hydrazides | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | RNA polymerase | en_US |
dc.subject | 1,3,4-Oxadiazoles | en_US |
dc.subject | Agents | en_US |
dc.subject | 4,6-Dimethoxyindoles | en_US |
dc.subject | Mild | en_US |
dc.title | Synthesis and biological evaluation of 2,5-di(7-indolyl)-1,3, 4-oxadiazoles, and 2-and 7-indolyl 2-(1,3,4-thiadiazolyl)ketones as antimicrobials | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Bioorganic & Medicinal Chemistry | en_US |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.authorid | 0000-0002-7347-2223 | |
dc.authorid | 0000-0001-9245-0356 | |
dc.authorid | 0000-0001-7739-5686 | |
dc.authorid | 0000-0002-0951-9621 | |
dc.authorid | 0000-0001-8137-9988 | |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 1672 | en_US |
dc.identifier.endpage | 1679 | en_US |
dc.institutionauthor | Kandemir, Hakan | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 55326408200 | |
dc.authorscopusid | 15071243800 | |
dc.authorscopusid | 36903739400 | |
dc.authorscopusid | 35516284500 | |
dc.authorscopusid | 7102951265 | |
dc.authorscopusid | 7402869005 | |
dc.authorscopusid | 16833488100 | |
dc.authorwosid | k, h/ABA-1339-2020 | |
dc.authorwosid | Ma, Cong/AAD-2439-2021 | |
dc.authorwosid | Griffith, Renate/A-3584-2015 | |
dc.identifier.wos | WOS:000331729500017 | en_US |
dc.identifier.scopus | 2-s2.0-84896699707 | en_US |
dc.identifier.pmid | 24525002 | en_US |