dc.contributor.author | Üstünova, Savaş | |
dc.contributor.author | Takır, Selçuk | |
dc.contributor.author | Yılmazer, Nadim | |
dc.contributor.author | Bulut, Huri | |
dc.contributor.author | Altındirek, Didem | |
dc.contributor.author | Hatırnaz, Özden | |
dc.contributor.author | Gürel Gürevin, Ebru | |
dc.date.accessioned | 2022-05-11T14:28:41Z | |
dc.date.available | 2022-05-11T14:28:41Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0258-851X | |
dc.identifier.issn | 1791-7549 | |
dc.identifier.uri | https://doi.org/10.21873/invivo.12067 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/6910 | |
dc.description.abstract | Background/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfiision (I/R) injury. Materials and Methods: Rat hearts were studied with the Langendorff technique using the H2S donor sodium hydrosulfide (NaHS, 40 mu M) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. Results: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. Conclusion: H2S and NO increase each other's production suggesting their interaction and cooperation in cardioprotection against I/R injury. | en_US |
dc.description.sponsorship | Scientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [31508, 55736, 47109] | en_US |
dc.description.sponsorship | This work was supported by Scientific Research Projects Coordination Unit of Istanbul University [grant numbers; 31508, 55736 and 47109]. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Int Inst Anticancer Research | en_US |
dc.identifier.doi | 10.21873/invivo.12067 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hydrogen sulfide | en_US |
dc.subject | nitric oxide | en_US |
dc.subject | isolated heart | en_US |
dc.subject | ischemia/reperfusion injury | en_US |
dc.subject | oxidative damage | en_US |
dc.subject | Ischemia-Reperfusion Injury | en_US |
dc.subject | H2s Protects | en_US |
dc.subject | Synthase | en_US |
dc.subject | Expression | en_US |
dc.subject | Inhibition | en_US |
dc.subject | Failure | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Mice | en_US |
dc.title | Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart | en_US |
dc.type | article | en_US |
dc.relation.ispartof | In Vivo | en_US |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.authorid | 0000-0002-7359-6568 | |
dc.authorid | 0000-0002-9130-9518 | |
dc.authorid | 0000-0001-5068-2968 | |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 2507 | en_US |
dc.identifier.endpage | 2516 | en_US |
dc.institutionauthor | Yılmazer, Nadim | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 23975103000 | |
dc.authorscopusid | 9243612600 | |
dc.authorscopusid | 6505825773 | |
dc.authorscopusid | 57185264300 | |
dc.authorscopusid | 57204107057 | |
dc.authorscopusid | 55040069600 | |
dc.authorscopusid | 57218758010 | |
dc.authorwosid | Armutak, Elif/D-2901-2019 | |
dc.identifier.wos | WOS:000574979000007 | en_US |
dc.identifier.scopus | 2-s2.0-85090182315 | en_US |
dc.identifier.pmid | 32871779 | en_US |