dc.contributor.author | Güzel, Savaş | |
dc.contributor.author | Seven, Arzu | |
dc.contributor.author | Kocaoglu, Ali | |
dc.contributor.author | İlk, Banu | |
dc.contributor.author | Güzel, Eda Çelik | |
dc.contributor.author | Saraçoğlu Varol, Gamze | |
dc.contributor.author | Çelebi, Asian | |
dc.date.accessioned | 2022-05-11T14:12:34Z | |
dc.date.available | 2022-05-11T14:12:34Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1479-1641 | |
dc.identifier.issn | 1752-8984 | |
dc.identifier.uri | https://doi.org/10.1177/1479164112440815 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/5601 | |
dc.description.abstract | Background: Diabetic patients often exhibit severe, asymptomatic coronary artery disease (CAD). The relationship between osteoprotegerin (OPG), inflammatory markers and silent myocardial ischemia remains to be elucidated. Methods: We recruited 45 type 2 diabetic patients and 33 healthy controls and assessed them for silent myocardial ischemia (SMI) by myocardial perfusion imaging. Patient blood was tested for OPG, IL-6 and leptin concentrations. Results: OPG, leptin and IL-6 levels were found significantly elevated in diabetic patients (p < 0.001, p < 0.01, p < 0.05). Based on our classification of presence/absence of SMI in our diabetic group, we found that there was a significant association between SMI and the biomarkers IL-6 (p <0.001), leptin (p<0.001) and OPG (p <0.05). In multivariate regression analyses, OPG was found to be significantly related to diabetes mellitus and to SMI. Age, sex and smoking increased the association between OPG and SMI. Conclusion: High OPG, leptin and IL-6 levels are associated with the presence and severity of SMI in type 2 diabetic patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage Publications Ltd | en_US |
dc.identifier.doi | 10.1177/1479164112440815 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | type 2 diabetes | en_US |
dc.subject | IL-6 | en_US |
dc.subject | leptin | en_US |
dc.subject | myocardial ischemia | en_US |
dc.subject | osteoprotegerin | en_US |
dc.subject | coronary artery disease | en_US |
dc.subject | Coronary-Artery Calcification | en_US |
dc.subject | Plasma Osteoprotegerin | en_US |
dc.subject | Circulating Osteoprotegerin | en_US |
dc.subject | Insulin Sensitivity | en_US |
dc.subject | Disease | en_US |
dc.subject | Risk | en_US |
dc.subject | Microalbuminuria | en_US |
dc.subject | Atherosclerosis | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Prevalence | en_US |
dc.title | Osteoprotegerin, leptin and IL-6: Association with silent myocardial ischemia in type 2 diabetes mellitus | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Diabetes & Vascular Disease Research | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 25 | en_US |
dc.identifier.endpage | 31 | en_US |
dc.institutionauthor | Güzel, Savaş | |
dc.institutionauthor | Seven, Arzu | |
dc.institutionauthor | Kocaoglu, Ali | |
dc.institutionauthor | İlk, Banu | |
dc.institutionauthor | Güzel, Eda Çelik | |
dc.institutionauthor | Saraçoğlu Varol, Gamze | |
dc.institutionauthor | Çelebi, Asian | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 23968920100 | |
dc.authorscopusid | 7003445991 | |
dc.authorscopusid | 55543290400 | |
dc.authorscopusid | 55543253700 | |
dc.authorscopusid | 42661653300 | |
dc.authorscopusid | 27968034900 | |
dc.authorscopusid | 15727384300 | |
dc.identifier.wos | WOS:000314327900004 | en_US |
dc.identifier.scopus | 2-s2.0-84871827823 | en_US |
dc.identifier.pmid | 22496403 | en_US |