dc.contributor.author | Bilir, Bülent | |
dc.contributor.author | Soysal Atile, Neslihan | |
dc.contributor.author | Bilir, Betül Ekiz | |
dc.contributor.author | Yılmaz, I. | |
dc.contributor.author | Bali, İlhan | |
dc.contributor.author | Altıntaş, Nejat | |
dc.contributor.author | Güldiken, Sibel | |
dc.contributor.author | Aydın, M. | |
dc.date.accessioned | 2022-05-11T14:09:56Z | |
dc.date.available | 2022-05-11T14:09:56Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1128-3602 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/5210 | |
dc.description.abstract | OBJECTIVE: This study was performed to investigate the levels of platelet activation marker SCUBE-1 and sCD40L which plays some role in the progression of atherosclerosis, in patients with hypothyroidism due to Hashimoto's thyroiditis. PATIENTS AND METHODS: The cohort of this study includes 90 patients and 35 healthy volunteers, who admitted to the internal medicine outpatient. Simultaneously in the same samples; SCUBE-1 and sCD40L measurements were accomplished by enzyme-linked immunosorbent assay (ELISA). The data obtained were analyzed statistically. RESULTS: Hypothyroidism due to Hashimoto's thyroiditis in comparison to the control group that includes healthy volunteers; SCUBE-1 and sCD40L, were increased. And these results were statistically significant (p < 0.05). CONCLUSIONS: SCUBE-1 and sCD40L levels were increased in Hashimoto's hypothyroidism patients. This may indicate an increased endothelial dysfunction, platelet activation and cardiovascular risk in hypothyroidism. SCUBE-1 and sCD40L may be helpful in cardiovascular risk assessment of hypothyroid patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Verduci Publisher | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cardiovascular risk | en_US |
dc.subject | sCD40L | en_US |
dc.subject | Hypothyroidism | en_US |
dc.subject | Hashimoto's thyroiditis | en_US |
dc.subject | SCUBE-1 | en_US |
dc.subject | Domain-Containing Protein-1 | en_US |
dc.subject | Acute Coronary Syndromes | en_US |
dc.subject | Subclinical Hypothyroidism | en_US |
dc.subject | Hypertensive Patients | en_US |
dc.subject | Platelet Activation | en_US |
dc.subject | Serum-Levels | en_US |
dc.subject | Peptide | en_US |
dc.subject | Endocan | en_US |
dc.subject | Risk | en_US |
dc.subject | Expression | en_US |
dc.title | Evaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto's thyroiditis: a single-blind, controlled clinical study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | European Review For Medical and Pharmacological Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-2003-6337 | |
dc.authorid | 0000-0003-2112-4056 | |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 407 | en_US |
dc.identifier.endpage | 413 | en_US |
dc.institutionauthor | Bilir, Bülent | |
dc.institutionauthor | Bali, İlhan | |
dc.institutionauthor | Altıntaş, Nejat | |
dc.institutionauthor | Aydın, M. | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56715752200 | |
dc.authorscopusid | 55556342300 | |
dc.authorscopusid | 57200105523 | |
dc.authorscopusid | 35197435300 | |
dc.authorscopusid | 55624501100 | |
dc.authorscopusid | 54892706700 | |
dc.authorscopusid | 53663196500 | |
dc.authorwosid | YILMAZ, Ibrahim/H-6199-2019 | |
dc.authorwosid | Baykız, Derya/ABD-7865-2020 | |
dc.authorwosid | Bilir, Bülent/AAK-5656-2021 | |
dc.identifier.wos | WOS:000371386300005 | en_US |
dc.identifier.scopus | 2-s2.0-84987629335 | en_US |
dc.identifier.pmid | 26914113 | en_US |