dc.contributor.author | Kara, Sonat Pınar | |
dc.contributor.author | Özkan, Gülsüm | |
dc.contributor.author | Emeksiz, Kübra | |
dc.contributor.author | Menteşe, A. | |
dc.contributor.author | Demir, S. | |
dc.contributor.author | Ulusoy, S. | |
dc.date.accessioned | 2022-05-11T14:05:02Z | |
dc.date.available | 2022-05-11T14:05:02Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1128-3602 | |
dc.identifier.uri | https://doi.org/10.26355/eurrev_202012_24183 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/4874 | |
dc.description.abstract | OBJECTIVE: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II autoantibodies have been linked to various autoimmune diseases. However, CA I and II autoantibody levels in primary HT have not been previously investigated. The purpose of this study was, therefore, to investigate levels of CA I and II autoantibodies in primary HT. PATIENTS AND METHODS: Fifty-six patients newly diagnosed with primary HT and 33 healthy individuals were included in the study. Twenty- four-hour ambulatory blood pressure monitoring was performed following office controls. Blood specimens were collected under appropriate conditions for CA I and II autoantibody level investigation and biochemical tests. Urine sodium and protein excretion were measured after 24 h. Demographic and biochemical parameters and CA I and II autoantibody levels were then compared between the patient and healthy groups. RESULTS: CA II autoantibody and uric acid levels were significantly higher in the hypertensive group than in the control group (p=0.005, and p<0.001, respectively). CA II autoantibody (exp ß: 79.06 CI: 4.44-1407.02) (p=0.003) and uric acid elevation (exp ß: 2.10 CI: 1.31- 3.34) (p=0.002) were identified as independent predictors of HT development at logistic regression analysis. CONCLUSIONS: CA II autoantibody levels were higher in hypertensive patients, and this elevation is an independent predictor of HT development. © 2020 Verduci Editore s.r.l. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Verduci Editore s.r.l | en_US |
dc.identifier.doi | 10.26355/eurrev_202012_24183 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | CA | en_US |
dc.subject | CA I autoantibody | en_US |
dc.subject | CA II autoantibody | en_US |
dc.subject | Carbonic anhydrase | en_US |
dc.subject | Hypertension | en_US |
dc.subject | autoantibody | en_US |
dc.subject | carbonate dehydratase I | en_US |
dc.subject | carbonate dehydratase II | en_US |
dc.subject | autoantibody | en_US |
dc.subject | sodium | en_US |
dc.subject | autoantibody | en_US |
dc.subject | carbonate dehydratase I | en_US |
dc.subject | carbonate dehydratase II | en_US |
dc.subject | adult | en_US |
dc.subject | antibody blood level | en_US |
dc.subject | antibody detection | en_US |
dc.subject | Article | en_US |
dc.subject | body mass | en_US |
dc.subject | controlled study | en_US |
dc.subject | enzyme blood level | en_US |
dc.subject | essential hypertension | en_US |
dc.subject | female | en_US |
dc.subject | human | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | predictive value | en_US |
dc.subject | protein function | en_US |
dc.subject | sodium urine level | en_US |
dc.subject | biochemistry | en_US |
dc.subject | blood analysis | en_US |
dc.subject | blood pressure monitoring | en_US |
dc.subject | demography | en_US |
dc.subject | enzymuria | en_US |
dc.subject | essential hypertension | en_US |
dc.subject | independent variable | en_US |
dc.subject | pathogenesis | en_US |
dc.subject | predictor variable | en_US |
dc.subject | blood | en_US |
dc.subject | hypertension | en_US |
dc.subject | metabolism | en_US |
dc.subject | middle aged | en_US |
dc.subject | Autoantibodies | en_US |
dc.subject | Carbonic Anhydrase I | en_US |
dc.subject | Carbonic Anhydrase II | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.title | Carbonic anhydrase I and II autoantibody levels in primary hypertension: Our preliminary results | en_US |
dc.type | article | en_US |
dc.relation.ispartof | European Review for Medical and Pharmacological Sciences | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 24 | en_US |
dc.identifier.startpage | 12821 | en_US |
dc.identifier.endpage | 12826 | en_US |
dc.institutionauthor | Özkan, Gülsüm | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57221503673 | |
dc.authorscopusid | 8570900600 | |
dc.authorscopusid | 57203191079 | |
dc.authorscopusid | 23489347700 | |
dc.authorscopusid | 55674801800 | |
dc.authorscopusid | 6603926071 | |
dc.identifier.wos | WOS:000601364400044 | en_US |
dc.identifier.scopus | 2-s2.0-85099321451 | en_US |
dc.identifier.pmid | 33378031 | en_US |