dc.contributor.author | Gönen, Tansu | |
dc.contributor.author | Güzel, Savaş | |
dc.contributor.author | Keskinbora, Kadircan Hıdır | |
dc.date.accessioned | 2022-05-11T14:04:54Z | |
dc.date.available | 2022-05-11T14:04:54Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0950-222X | |
dc.identifier.uri | https://doi.org/10.1038/s41433-018-0308-8 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/4832 | |
dc.description.abstract | Purpose: To investigate the YKL-40, as a marker of inflammation, in aqueous humor and serum of cataract patients with and without pseudoexfoliation syndrome (PEX). Methods: Aqueous humor and serum samples were obtained from 44 patients who underwent phacoemulsification surgery. All patients were divided into two groups: PEX (n = 24) and control (n = 20). YKL-40 levels were measured with enzyme-linked immunosorbent assay (ELISA). The differences between the groups were assessed by using Chi-square and independent sample t-tests. The Pearson correlation coefficient was used to evaluate the correlation between variables. Results: There was a significant difference between the mean YKL-40 levels in the aqueous humor of PEX group (112.0 ± 35.8 ng/mL) and control subjects (88.2 ± 30.6 ng/mL) (P = 0.025). However, the difference between the mean YKL-40 levels in the serum of PEX group (53.5 ± 29.1 ng/mL) and control subjects (44.6 ± 30.2 ng/mL) was non-significant (P = 0.326). The correlation between aqueous humor and serum YKL-40 concentrations was significant in both the groups (r = 0.833, P < 0.001; r = 0.840, P < 0.001, respectively). Conclusions: Increased aqueous humor levels of YKL-40 demonstrate that it is local, but not a systemic marker for inflammation in patients with PEX. © 2018, The Royal College of Ophthalmologists. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.identifier.doi | 10.1038/s41433-018-0308-8 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | biological marker | en_US |
dc.subject | chitinase 3 like protein 1 | en_US |
dc.subject | tropicamide | en_US |
dc.subject | biological marker | en_US |
dc.subject | CHI3L1 protein, human | en_US |
dc.subject | chitinase 3 like protein 1 | en_US |
dc.subject | growth promotor | en_US |
dc.subject | aged | en_US |
dc.subject | anterior lens capsule | en_US |
dc.subject | aqueous humor | en_US |
dc.subject | Article | en_US |
dc.subject | blood sampling | en_US |
dc.subject | case control study | en_US |
dc.subject | cataract | en_US |
dc.subject | clinical article | en_US |
dc.subject | college | en_US |
dc.subject | controlled study | en_US |
dc.subject | correlation coefficient | en_US |
dc.subject | enzyme linked immunosorbent assay | en_US |
dc.subject | eye examination | en_US |
dc.subject | female | en_US |
dc.subject | gonioscopy | en_US |
dc.subject | human | en_US |
dc.subject | inflammation | en_US |
dc.subject | intraocular pressure | en_US |
dc.subject | laboratory test | en_US |
dc.subject | male | en_US |
dc.subject | ophthalmoscopy | en_US |
dc.subject | phacoemulsification | en_US |
dc.subject | prospective study | en_US |
dc.subject | protein blood level | en_US |
dc.subject | pseudoexfoliation | en_US |
dc.subject | senile cataract | en_US |
dc.subject | serum | en_US |
dc.subject | slit lamp microscopy | en_US |
dc.subject | tonometry | en_US |
dc.subject | blood | en_US |
dc.subject | inflammation | en_US |
dc.subject | metabolism | en_US |
dc.subject | pseudoexfoliation | en_US |
dc.subject | very elderly | en_US |
dc.subject | Aged | en_US |
dc.subject | Aged, 80 and over | en_US |
dc.subject | Aqueous Humor | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Case-Control Studies | en_US |
dc.subject | Cataract | en_US |
dc.subject | Chitinase-3-Like Protein 1 | en_US |
dc.subject | Enzyme-Linked Immunosorbent Assay | en_US |
dc.subject | Exfoliation Syndrome | en_US |
dc.subject | Female | en_US |
dc.subject | Growth Substances | en_US |
dc.subject | Humans | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Male | en_US |
dc.subject | Phacoemulsification | en_US |
dc.subject | Prospective Studies | en_US |
dc.title | YKL-40 is a local marker for inflammation in patients with pseudoexfoliation syndrome | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Eye (Basingstoke) | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 772 | en_US |
dc.identifier.endpage | 776 | en_US |
dc.institutionauthor | Gonen, Tansu | |
dc.institutionauthor | Keskinbora, Kadircan Hıdır | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 34869701000 | |
dc.authorscopusid | 23968920100 | |
dc.authorscopusid | 55913025800 | |
dc.identifier.wos | WOS:000467229300013 | en_US |
dc.identifier.scopus | 2-s2.0-85058786152 | en_US |
dc.identifier.pmid | 30560917 | en_US |