dc.contributor.author | Bıçakçı, N. | |
dc.contributor.author | Karaboğa, İhsan | |
dc.contributor.author | Dökmeci, Ayşe Handan | |
dc.contributor.author | Güzel, S. | |
dc.contributor.author | Fidanol Erboğa, Z. | |
dc.date.accessioned | 2022-05-11T14:02:43Z | |
dc.date.available | 2022-05-11T14:02:43Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1052-0295 | |
dc.identifier.uri | https://doi.org/10.1080/10520295.2019.1586999 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/4453 | |
dc.description.abstract | We investigated the effects of caffeic acid phenethyl ester (CAPE) on cardiac damage after blunt chest injury. Forty male adult Wistar albino rats were divided into four groups; control, cardiac contusion, cardiac contusion + CAPE, and CAPE. CAPE, 10 mmol/kg, was administered intraperitoneally for 7 days following cardiac contusion. Heart tissue and blood were obtained at the end of the experimental period. Cardiac histopathology was determined using hematoxylin & eosin (H & E) staining. Expression of tumor necrosis factor-alpha (TNF-?) in cardiomyocytes was determined using immunohistochemistry. Cardiac apoptosis was determined using the TUNEL method. Serum creatine kinase (CK), creatine kinase-muscle/brain (CK-MB) and lactate dehydrogenase (LDH) levels were determined using spectrophotometric methods. The serum cardiac troponin I (C-TI) level was measured using the ELISA method. Myofibril loss was detected in the cardiomyocytes of the cardiac contusion group. Increased apoptosis and TNF-? expression were observed in the cardiac contusion group compared to the control group. Increased CK, CK-MB, LDH and C-TI levels were found in the cardiac contusion group. We found that CAPE administration improved myocardial function. Compared to the cardiac contusion group, CK, CK-MB, LDH and C-TI levels decreased significantly in the cardiac contusion + CAPE group. Administration of CAPE significantly inhibited apoptosis and cardiac TNF-? expression. Our findings demonstrate the therapeutic effects of CAPE for cardiac contusion damage after blunt chest trauma. © 2019, © 2019 The Biological Stain Commission. | en_US |
dc.description.sponsorship | 18,16 | en_US |
dc.description.sponsorship | Our study was supported by Tekirdag Nam?k Kemal University, Scientific Research Projects Commission, Project number; NKUBAP.23.GA.18.160. | en_US |
dc.description.sponsorship | Our study was supported by Tekirdag Namık Kemal University, Scientific Research Projects Commission, Project number; NKUBAP.23.GA.18.160. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis Ltd | en_US |
dc.identifier.doi | 10.1080/10520295.2019.1586999 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | caffeic acid phenethyl ester | en_US |
dc.subject | cardiac contusion | en_US |
dc.subject | contusion | en_US |
dc.subject | rats | en_US |
dc.subject | TNF-? | en_US |
dc.subject | troponin - I | en_US |
dc.subject | antioxidant | en_US |
dc.subject | caffeic acid derivative | en_US |
dc.subject | caffeic acid phenethyl ester | en_US |
dc.subject | phenethyl alcohol | en_US |
dc.subject | animal | en_US |
dc.subject | apoptosis | en_US |
dc.subject | blunt trauma | en_US |
dc.subject | cardiac muscle | en_US |
dc.subject | drug effect | en_US |
dc.subject | heart | en_US |
dc.subject | heart contusion | en_US |
dc.subject | male | en_US |
dc.subject | metabolism | en_US |
dc.subject | thorax injury | en_US |
dc.subject | Wistar rat | en_US |
dc.subject | Animals | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Caffeic Acids | en_US |
dc.subject | Heart | en_US |
dc.subject | Male | en_US |
dc.subject | Myocardial Contusions | en_US |
dc.subject | Myocardium | en_US |
dc.subject | Phenylethyl Alcohol | en_US |
dc.subject | Rats, Wistar | en_US |
dc.subject | Thoracic Injuries | en_US |
dc.subject | Wounds, Nonpenetrating | en_US |
dc.title | Cardioprotective effect of caffeic acid phenethyl ester on cardiac contusion following blunt chest trauma in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Biotechnic and Histochemistry | en_US |
dc.department | Yüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 94 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 442 | en_US |
dc.identifier.endpage | 448 | en_US |
dc.institutionauthor | Bıçakçı, N. | |
dc.institutionauthor | Karaboğa, İhsan | |
dc.institutionauthor | Dökmeci, Ayşe Handan | |
dc.institutionauthor | Güzel, S. | |
dc.institutionauthor | Fidanol Erboğa, Z. | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57208033518 | |
dc.authorscopusid | 55838809000 | |
dc.authorscopusid | 26434143900 | |
dc.authorscopusid | 23968920100 | |
dc.authorscopusid | 56659422100 | |
dc.identifier.wos | WOS:000483618700008 | en_US |
dc.identifier.scopus | 2-s2.0-85063644853 | en_US |
dc.identifier.pmid | 30929510 | en_US |