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Royal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model

dc.contributor.authorDuran, Y.
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorPolat, Fatin Rüştü
dc.contributor.authorPolat, E.
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorOvalı, M. A.
dc.contributor.authorYılmaz, A.
dc.contributor.authorÇelikkol, A.
dc.date.accessioned2022-05-11T14:01:33Z
dc.date.available2022-05-11T14:01:33Z
dc.date.issued2020
dc.identifier.issn0301-4851
dc.identifier.urihttps://doi.org/10.1007/s11033-020-05939-w
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4434
dc.description.abstractThe aim of the study was to investigate traditionally used Royal Jelly (RJ) for treating an ethanol-induced gastric ulcer model in rats. A total of 32 Wistar albino male rats were divided into 4 groups of 8: group I = Control, group II = Ethanol, group III = RJ + Ethanol, and group IV = Lansoprazole + Ethanol. In groups II, III, and IV, animals were administered 1 ml of absolute ethanol orally after a 24-h fast to induce ulcer formation. The histopathological changes in the gastric mucosa were determined using hematoxylin-eosin (H&E) staining. Immunohistochemically, inducible nitric oxide (iNOS) and nuclear factor kappa beta (Nf-??) markings were evaluated in gastric tissue. Cell death in the gastric mucosa was determined by the TUNEL method. Oxidative status markers, superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), and myeloperoxidase (MPO) levels were determined spectrophotometrically. Expression of the interleukin – 1 beta (IL-1?) and tumor necrosis factor-? (TNF-?) genes in gastric tissues was determined by real-time PCR; and TNF-?, IL-10, and IL-1? levels were determined. RJ was found to inhibit iNOS and Nf-?? activity in the gastric mucosa and prevent epithelial cell apoptosis. In particular, pro-inflammatory cytokines TNF-? and IL-1? levels were significantly decreased in the RJ + Ethanol group compared to the Ethanol group. In addition, a decrease in the MPO level indicated that RJ prevented tissue damage, especially by preventing inflammatory cell infiltration. The study demonstrated a possible gastroprotective effect of RJ in a rat ethanol-induced gastric ulcer model. © 2020, Springer Nature B.V.en_US
dc.description.sponsorshipThis work was supported by the Research Fund of the Tekirda? Nam?k Kemal University. Project Number: NKUBAP.02.GA.18.181.en_US
dc.description.sponsorshipThis work was supported by the Research Fund of the Tekirdağ Namık Kemal University. Project Number: NKUBAP.02.GA.18.181.en_US
dc.language.isoengen_US
dc.publisherSpringer Science and Business Media B.V.en_US
dc.identifier.doi10.1007/s11033-020-05939-w
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectGastric ulceren_US
dc.subjectInducible nitric oxide synthaseen_US
dc.subjectNuclear factor-kappa betaen_US
dc.subjectRoyal Jellyen_US
dc.subjectcatalaseen_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjectinterleukin 10en_US
dc.subjectinterleukin 1betaen_US
dc.subjectlansoprazoleen_US
dc.subjectmalonaldehydeen_US
dc.subjectmyeloperoxidaseen_US
dc.subjectroyal jellyen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecttumor necrosis factoren_US
dc.subjectalcoholen_US
dc.subjectcatalaseen_US
dc.subjectcentral depressant agenten_US
dc.subjectcytokineen_US
dc.subjectfatty aciden_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectmalonaldehydeen_US
dc.subjectroyal jellyen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectadulten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectcell deathen_US
dc.subjectcontrolled studyen_US
dc.subjectenzyme activityen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectepithelium cellen_US
dc.subjectethanol-induced gastric ulceren_US
dc.subjectgene expressionen_US
dc.subjecthematoxylin eosin stainingen_US
dc.subjecthistopathologyen_US
dc.subjectIL 1beta geneen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectprotein blood levelen_US
dc.subjectprotein expressionen_US
dc.subjectraten_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectspectrophotometryen_US
dc.subjectstainingen_US
dc.subjectstomach protectionen_US
dc.subjectTNF alpha geneen_US
dc.subjecttranscription initiationen_US
dc.subjectTUNEL assayen_US
dc.subjectWistar raten_US
dc.subjectanimalen_US
dc.subjectdisease modelen_US
dc.subjectdrug effecten_US
dc.subjectgeneticsen_US
dc.subjectinjuryen_US
dc.subjectmetabolismen_US
dc.subjectoxidative stressen_US
dc.subjectstomach mucosaen_US
dc.subjectstomach ulceren_US
dc.subjectAnimalsen_US
dc.subjectApoptosisen_US
dc.subjectCatalaseen_US
dc.subjectCentral Nervous System Depressantsen_US
dc.subjectCytokinesen_US
dc.subjectDisease Models, Animalen_US
dc.subjectEthanolen_US
dc.subjectFatty Acidsen_US
dc.subjectGastric Mucosaen_US
dc.subjectGene Expressionen_US
dc.subjectMaleen_US
dc.subjectMalondialdehydeen_US
dc.subjectNF-kappa Ben_US
dc.subjectOxidative Stressen_US
dc.subjectRats, Wistaren_US
dc.subjectStomach Ulceren_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleRoyal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury modelen_US
dc.typearticleen_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümüen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.identifier.volume47en_US
dc.identifier.issue11en_US
dc.identifier.startpage8867en_US
dc.identifier.endpage8879en_US
dc.institutionauthorDuran, Y.
dc.institutionauthorKaraboğa, İhsan
dc.institutionauthorPolat, Fatin Rüştü
dc.institutionauthorPolat, E.
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorOvalı, M. A.
dc.institutionauthorYılmaz, A.
dc.institutionauthorÇelikkol, A.
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57212512972
dc.authorscopusid55838809000
dc.authorscopusid8855691800
dc.authorscopusid56727936300
dc.authorscopusid56816914100
dc.authorscopusid55897728300
dc.authorscopusid57191922068
dc.identifier.wosWOS:000584364400002en_US
dc.identifier.scopus2-s2.0-85094844653en_US
dc.identifier.pmid33135128en_US


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