Kurum Yazarı "Bozgeyik, Esra" Tıp Fakültesi Koleksiyonu İçin Listeleme
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ARID3A-mediated modulation of TP73 and TP73-AS1 in osteosarcoma cells
Saadat, Khandakar A.S.M.; Bozgeyik, Esra; Arman, Kaifee; Bozgeyik, İbrahim; İkeda, M.A. (Elsevier Inc, 2020)Osteosarcoma is the most common primary malignancy arising from bone. Increasing mass of indications suggest that long non-coding RNAs (lncRNAs) play crucial roles in the development of progressions of human cancers including ... -
Bioinformatic Analysis and in Vitro Validation of Let-7b and Let-7c in Breast Cancer
Bozgeyik, Esra (Elsevier Ltd, 2020)Members of the let-7 family of miRNAs are well-known with their tumor suppressor properties as they are expressed at low levels in several types of human malignancies. Among them, let-7b and let-7c have gained special ... -
Cross-regulation of non-coding RNAs and their correlations with target protein-coding genes in CRC pathobiology
Bozgeyik, Esra; Bozgeyik, İbrahim (Elsevier B.V., 2019)Illuminating the correlations between non-coding RNAs and protein-coding genes are of great interest to understand more about the molecular mechanisms that drive malignant transformation and understanding such correlations ... -
Enhanced E2F1 activity increases invasive and proliferative activity of breast cancer cells through non-coding RNA CDKN2B-AS1
Bozgeyik, Esra; Saadat, Khandakar A.S.M.; Arman, K.; Bozgeyik, İbrahim; İkeda, M.A. (Elsevier B.V., 2020)Long non-coding RNAs have recently appeared as fundamental regulators of gene transcription in several biological processes, but only a few have known functional influences in the malignant transformation of breast cancer. ... -
Kanserin Ayırt Edici Özelliklerinde Kodlanmayan RNA'ların Rolü: Güncel Bir Bakış
Bozgeyik, Esra (2020)Kanser, genomda meydana gelen bir seri bozukluklar sonucu ortaya çıkan ciddi bir genetik hastalıktır. Yüksek verimli yeni nesil dizileme teknolojilerinin geliştirilmesi ve büyük ölçekli projelerin verilerinin yayınlanması ... -
Küçük Hücreli Olmayan Akciğer Kanseri Hücrelerinde Let-7b-5p'nin Apoptotik Genler İle İlişkisinin Araştırılması
Bozgeyik, Esra (2019)Amaç: Akciğer kanseri dünya genelinde kansere bağlı gerçekleşen ölümlerde kadınlarda ve erkeklerde ilk sıralarda yer almaktadır. Erken tanı yöntemlerinde ki gelişmeler ve yeni hedeflenen ajanların sayısının artmasına rağmen ... -
MicroRNA-17-5p targets expression of cancer-associated genes in breast cancer cells
Bozgeyik, Esra (Elsevier B.V., 2020)Although there are several studies, biological function and therapeutic potential of miR-17-5p in breast cancer carcinogenesis remains muchly elusive. Specifically, its interaction with several cancer-associated genes ... -
MIRNA-mediated regulation of the PI3K/AKT signaling pathway in colorectal cancer: A study based on data mining
Bozgeyik, Esra; Bozgeyik, İbrahim (2019)Aim: In colorectal cancer (CRC), expression of genes involved in the PI3K/Akt signaling pathway varies significantly. Studies haveshown that microRNAs (miRNA) have important roles in the development of CRC. Accordingly, ... -
Next generation sequencing analysis of BRCA1 and BRCA2 identifies novel variations in breast cancer
Yıldız Tacar, Seher; Bozgeyik, Esra; Şeber, Erdoğan Selçuk; Yetişyiğit, Tarkan; Tozkır, Hilmi; Avcı, Okan; Arslan, Ahmet (Elsevier Inc., 2020)Mutations in two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified to be the most important predisposing factors for the development of breast cancer. Thus, BRCA1/2 testing is a well-established ... -
Next-generation screening of a panel of genes associated with periodic fever syndromes in patients with Familial Mediterranean Fever and their clinical characteristics
Bozgeyik, Esra; Mercan, Rıdvan; Arslan, A.; Tozkır, Hilmi (Academic Press Inc., 2020)Familial Mediterranean Fever (FMF) is a hereditary fever syndrome that primarily affects Mediterranean populations. For the study, total number of 182 patients with FMF disease were enrolled and screening of a panel of ... -
Novel thiosemicarbazone derivative 17B interferes with the cell cycle progression and induce apoptosis through modulating downstream signaling pathways
Bozgeyik, Esra; Taşdemir Kahraman, Demet; Arman, Kaifee; Bozgeyik, İbrahim; Karaküçük İyidoğan, Ayşegül; Çakmak, Ecir Ali (Elsevier, 2020)Thiosemicarbazones (TSCs) are interesting group of chemical compounds that received significant levels of attention due their wide range of pharmacological effects including antibacterial, antiviral, and especially anti-tumor ... -
Prostat Kanseri Moleküler Mekanizmasında Kodlanmayan Rna'ların Rolü
Bozgeyik, Esra (2019)Kodlanmayan RNA’lar (ncRNA), bir açık okuma çerçevesibulunmayan ve proteine çevrilemeyen işlevsel RNAtranskriptleridir. NcRNA’lar transkripsiyon ve transkripsiyonsonrası işlemlerde düzenleyici rollere ve halenaçıklanmaya ...