Kurum Yazarı "Karaarslan, Numan" Tıp Fakültesi Koleksiyonu İçin Listeleme
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Evaluation of the effect of apixaban on the primary intact intervertebral disc cell cultures
Akgün, Feride Sinem; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Şirin, Duygu Yaşar; Şimşek, Abdullah Talha; Ateş, Özkan (2019)Aim: Apixaban is a frequently preferred pharmacological agent in clinics to prevent deep vein thrombosis and pulmonary embolism.Such new oral anticoagulants may cause hemorrhage’s in tissues and/or organs or may cause ... -
Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue
Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Yasar Şirin, Duygu; Şimşek, Abdullah Talha; Çalışkan, Tezcan; Özbek, Hanefi (Turkish Neurosurgical Soc, 2019)AIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using ... -
Evaluation of the effects of pregabalin on chondrocyte proliferation and CHAD, HIF-1 alpha, and COL2A1 gene expression
Şirin, Duygu Yaşar; Karaarslan, Numan (Termedia Publishing House Ltd, 2018)Introduction: The aim of the present study is to investigate the effects of pregabalin (PGB) on chondrocyte proliferation and collagen type II (COL2A1), hypoxia-inducible factor 1-alpha (HIF-1 alpha), and chondroadherin ... -
Evaluation of the expression and proliferation of degenerative markers in primary cell cultures obtained from human intervertebral disc tissue
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahi?m; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi (2020)Aim: A major cause of low back pain is disc degeneration. Nevertheless, no specific and reliable markers of the degeneration of thenucleus pulposus (NP) are available. This presented study aimed to examine changes in the ... -
In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
Kaya, Yasin Emre; Yılmaz, İbrahi?m; Karaarslan, Numan; Bilir, Bülent; Şirin, Duygu Yaşar; Özbek, Hanefi (2020)Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained ... -
Intraabdominal Pseudocyst Developed after Ventriculoperitoneal Shunt: A Case Report
Ayan, Erdoğan; Tanriverdi, Halil İbrahim; Çalışkan, Tezcan; Senel, Ufuk; Karaarslan, Numan (Premchand Shantidevi Research Foundation, 2015)Abdominal pseudocyst is a rare complication developing after ventriculoperitoneal shunt treatment. It is more commonly seen particularly in children. The underlying pathogenesis may be associated with repeat revisions or ... -
Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue
Akgün, Feride Sinem; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Şimşek, Abdullah Talha; Ateş, Özkan; Çalışkan, Tezcan (Spandidos Publ Ltd, 2019)The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells in vitro. After surgical ... -
Investigation of the Effects of Methylphenidate, an Amphetamine Derivative, on Intervertebral Disc Tissue Cell Cultures and Matrix Structures
Kaya, Yasin Emre; Karaarslan, Numan; Yasar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Yılmaz, İbrahim (Turkish Neurosurgical Soc, 2019)AIM: To investigate the effects of methylphenidate (MPH), on intervertebral disc tissue (IVD) cell cultures and extracellular matrix structures. Changes in the expression of some important marker genes involved in anabolic ... -
Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Yaman, Onur; Özbek, Hanefi; Ateş, Özkan (2020)AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells ... -
Is Implant Washing and Wound Irrigation with Rifampicin Effective for Preventing Surgical Site Infections in Lumbar Instrumentation?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Öznam, Kadir; Ateş, Özkan; Erdem, İlknur (Turkish Neurosurgical Soc, 2018)AIM: To determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant ... -
Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems?
Topuk, Savaş; Akyuva, Yener; Karaarslan, Numan; Mutlu, Çağrı A.; Yılmaz, İbrahim; İşyar, Mehmet; Mahiroğulları, Mahir (Bentham Science Publ Ltd, 2017)Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small ... -
Lumbar spinal angiolipoma with expanding left neural foramen mimicking lumbar schwannoma; case report and review of the literature
Akyuva, Yener; Gönültaş, Aylin; Karaarslan, Numan; Gülçiftçi Dağcı, Zeliha; Sağlık, Semih; İşyar, Mehmet; Mahiroğulları, Mahir (Bentham Science Publishers B.V., 2017)Aim: To describe a patient with lumbar angiolipoma mimicking schwannoma in the posterolateral side of the spinal canal with expansion of the left lumbar foramen and to discuss the clinical, radiologic, and surgical features ... -
Pharmaco-molecular assessment of the effects of anandamide and its antagonists on hippocampal tissue in Wistar albino rats
Yılmaz, İbrahim; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi (Verduci Publisher, 2020)OBJECTIVE: The members of the matrix metalloproteinase (MMP) family and cannabinoids (CBs) are reportedly associated with hippocampus-dependent memory functions. However, the effects of endogenously formed CBs on hippocampal ... -
Postoperative analgesic effect of bupivacaine infiltration following lumbar disc surgery
Objectives: Effectiveness of 0.5% bupivacaine administered onto dura, under lumbar superficial fascia andsubcutaneous tissue on postoperative pain control was analyzed in patients undergoing lumbar microdiscectomy.Methods: ... -
Practical Performance of Hippocampal Tissue Resection in Rats in Pharmacomolecular Research
Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi (Turkish Neurosurgical Soc, 2021)AIM: To explain how to resect hippocampal tissue in rats used as live mammalian subjects for the resection of fresh cerebral tissue in laboratories. MATERIAL and METHODS: Adult male Wistar-Albino rats (n=50) were used for ... -
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Özbek, Hanefi; Kaplan, Necati; Kaya, Yasin Emre; Ateş, Özkan (Spandidos Publ Ltd, 2018)The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clinicians, exert toxic effects on human primary nucleus ... -
Remote Cerebellar Haemorrhage after Burr Hole Drainage of Chronic Subdural Haematoma: A Case Report
Gürbüz, Mehmet Sabri; Karaarslan, Numan; Gök, Sevki; Soyalp, Celaleddin (Premchand Shantidevi Research Foundation, 2016)Remote cerebellar haemorrhage (RCH) is an unusual complication of supratentorial neurosurgical procedures. Even the rarer is cerebellar haemorrhage occurring after supratentorial burr hole drainage of Chronic Subdural ... -
Remote Cerebellar Haemorrhage Occurring after Transcranial Pituitary Surgery
Karaarslan, Numan; Gürbüz, Mehmet Sabri; Çalışkan, Tezcan; Tunckale, Tamer (Premchand Shantidevi Research Foundation, 2017)Post supratentorial and spinal surgeries, in rare cases, Remote Cerebellar Haemorrhage (RCH) develops as a complication. Although the exact aetiology of RCH remains uncertain, excessive drainage of the Cerebrospinal Fluid ... -
Sequestrectomy or microdiscectomy in patients with lumbar disc herniation
Somay, Hakan; Karaarslan, Numan (2019)Aim: Which microsurgical method can provide better outcomes for patients with lumbar disc herniation (LDH) is still unclear in the literature. In the present study, the aim was to retrospectively examine the efficacy of ... -
Severe head trauma in children: Analysis of 68 cases in light of current guidelines
Gürbüz, Mehmet Sabri; Duyu, Muhterem; Gezen, Ahmet Ferruh; Canızcı Erdemli, Pınar; Boşnak, Ercan; Elias, Çimen; Karaarslan, Numan (2020)Aim: To assess the characteristics of severe head trauma in the pediatric age group and to analyze its results under the currentguideline.Material and Methods: Eighty pediatric patients (<18 years) admitted to our hospital ...