Bölüm "Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı" Tıp Fakültesi Koleksiyonu için listeleme
Toplam kayıt 28, listelenen: 1-20
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22.5 MB DELETION OF 13q31.1-q34 ASSOCIATED WITH HPE, DWM, AND HSCR: A CASE REPORT AND REDEFINING THE SMALLEST DELETED REGIONS
(Medecine Et Hygiene, 2016)22.5 MB deletion of 13q31.1-q34 associated with HPE, DWM, and HSCR: A case report and redefining the smallest deleted regions: Partial deletion of the long arm of the chromosome 13, 13q deletion syndrome is a rare chromosomal ... -
22.5 MB deletion of 13q31.1-q34 associated with HPE, DWM, and HSCR: A case report and redefining the smallest deleted regions
(Editions Medecine et Hygiene, 2016)22.5 MB deletion ofliqil. l-qi4 associated with HPE, DWM, and HSCR: A case report and redefining the smallest deleted regions: Partial deletion of the long arm of the chromosome 13, 13q deletion syndrome is a rare chromosomal ... -
Altered methyltetrahydrofolate reductase gene polymorphism in mothers of children with attention deficit and hyperactivity disorder
(Pergamon-Elsevier Science Ltd, 2019)Attention Deficit and Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood and causes significant functional impairments in children. Behavioral genetic and molecular genetic studies ... -
ARID3A-mediated modulation of TP73 and TP73-AS1 in osteosarcoma cells
(Elsevier Inc, 2020)Osteosarcoma is the most common primary malignancy arising from bone. Increasing mass of indications suggest that long non-coding RNAs (lncRNAs) play crucial roles in the development of progressions of human cancers including ... -
Association of a point mutation (m.9176T > G) of the MT-ATP6 gene with Leigh syndrome: A case report
(Biomedpress, 2020)Leigh Syndrome (LS) is an uncommon progressive neurodegenerative mitochondrial disorder. The condition is characterized by progressive mental and developmental disabilities (psychomotor regression) and commonly brings about ... -
Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer
(Hindawi Ltd, 2022)Background. Breast cancer is the most common malignancy in women. Genetic risk factors associated with breast cancer incidence have been identified. Aims. This study is aimed at determining the association of XRCC3 Thr241Met ... -
Bioinformatic Analysis and in Vitro Validation of Let-7b and Let-7c in Breast Cancer
(Elsevier Ltd, 2020)Members of the let-7 family of miRNAs are well-known with their tumor suppressor properties as they are expressed at low levels in several types of human malignancies. Among them, let-7b and let-7c have gained special ... -
Cross-regulation of non-coding RNAs and their correlations with target protein-coding genes in CRC pathobiology
(Elsevier B.V., 2019)Illuminating the correlations between non-coding RNAs and protein-coding genes are of great interest to understand more about the molecular mechanisms that drive malignant transformation and understanding such correlations ... -
DNA repair and apoptosis: Roles in radiotherapy-related acute reactions in breast cancer patients
(C M B Assoc, 2018)Normal tissue reactions are therapy limiting factor for the effectiveness of the radiotherapy in cancer patients. DNA repair and apoptosis are estimated to be critical players of adverse effects in response to radiotherapy. ... -
Does the serotonin receptor gene (rs6313 and rs6314) polymorphism have a role in suicidal attempts?
(Elsevier Sci Ltd, 2018)Suicide is an important public health problem. The aim of the present study is to determine the incidence of serotonin receptor gene polymorphisms (rs6313 and rs6314) in patients with a history of suicide attempt by blood ... -
Enhanced E2F1 activity increases invasive and proliferative activity of breast cancer cells through non-coding RNA CDKN2B-AS1
(Elsevier B.V., 2020)Long non-coding RNAs have recently appeared as fundamental regulators of gene transcription in several biological processes, but only a few have known functional influences in the malignant transformation of breast cancer. ... -
Expression level of UCMA as a candidate molecular target in osteoarthritis
(2021)Aim: Osteoarthritis (OA) is a degenerative joint disorder that damages cartilage, synovium and subchondral bone, and there is yet no effective treatment for OA. The identification of novel therapeutic methods is crucially ... -
Geç Tanili Rubinstein-Taybi Sendromlu Bir Olgu
(2017)Rubinstein-Taybi Sendromu (RSTS) karakteristik yüz bulgulari, kisa boy, orta-ağir entelektüel yetersizlik, geniş el ve ayak başparmaklari ile seyreden nadir bir genetik hastaliktir. Hastalarin yaşamlarinin ilk yillarinda ... -
Kanserin Ayırt Edici Özelliklerinde Kodlanmayan RNA'ların Rolü: Güncel Bir Bakış
(2020)Kanser, genomda meydana gelen bir seri bozukluklar sonucu ortaya çıkan ciddi bir genetik hastalıktır. Yüksek verimli yeni nesil dizileme teknolojilerinin geliştirilmesi ve büyük ölçekli projelerin verilerinin yayınlanması ... -
Küçük Hücreli Olmayan Akciğer Kanseri Hücrelerinde Let-7b-5p'nin Apoptotik Genler İle İlişkisinin Araştırılması
(2019)Amaç: Akciğer kanseri dünya genelinde kansere bağlı gerçekleşen ölümlerde kadınlarda ve erkeklerde ilk sıralarda yer almaktadır. Erken tanı yöntemlerinde ki gelişmeler ve yeni hedeflenen ajanların sayısının artmasına rağmen ... -
MicroRNA-17-5p targets expression of cancer-associated genes in breast cancer cells
(Elsevier B.V., 2020)Although there are several studies, biological function and therapeutic potential of miR-17-5p in breast cancer carcinogenesis remains muchly elusive. Specifically, its interaction with several cancer-associated genes ... -
MIRNA-mediated regulation of the PI3K/AKT signaling pathway in colorectal cancer: A study based on data mining
(2019)Aim: In colorectal cancer (CRC), expression of genes involved in the PI3K/Akt signaling pathway varies significantly. Studies haveshown that microRNAs (miRNA) have important roles in the development of CRC. Accordingly, ... -
Molecular approaches in COVID-19 treatment
(Nova Science Publishers, Inc., 2021)Coronaviruses are a family of enveloped RNA viruses that cause diseases in various mammals and birds. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus identified as the cause of a global ... -
Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin
(Amer Soc Clinical Investigation Inc, 2016)BACKGROUND. Arthrogryposis, defined as congenital, joint contractures in 2 or more body areas, is a clinical sign rather than a specific disease diagnosis. To date, more than 400 different disorders have been described ... -
Next generation sequencing analysis of BRCA1 and BRCA2 identifies novel variations in breast cancer
(Elsevier Inc., 2020)Mutations in two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified to be the most important predisposing factors for the development of breast cancer. Thus, BRCA1/2 testing is a well-established ...