ORCID "0000-0001-5291-8620" Fen Edebiyat Fakültesi Koleksiyonu için listeleme
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9 Years Follow-up of a Patient with Pituitary Form of Resistance to Thyroid Hormones (PRTH): Comparison of Two Treatment Periods of D-Thyroxine and Triiodothyroacetic Acid (TRIAC)
Güran, Tülay; Turan, Serap; Bircan, Rifat; Bereket, Abdullah (Walter De Gruyter Gmbh, 2009)Patients with pituitary resistance to thyroid hormones (PRTH) exhibit features of hyperthyroidism due to normal sensitivity to thyroid hormones in some of the peripheral tissues. There is a lack of information in the ... -
Alopecia: Association with Resistance to Thyroid Hormones
Güran, Tülay; Bircan, Rifat; Turan, Serap; Bereket, Abdullah (Freund Publishing House Ltd, 2009)Resistance to thyroid hormone (RTH) syndrome is caused by thyroid hormone beta receptor (TR beta) mutations. Goiter, learning disabilities, psychological abnormalities, sinus tachycardia, hearing deficits, short stature, ... -
Angiotensin Converting Enzyme Gene Polymorphism in Turkish Asthmatic Patients
Eryuksel, Emel; Ceyhan, Berrin Bagci; Bircan, Rifat; Avşar, Melike; Çirakoğlu, Beyazıt (Taylor & Francis Inc, 2009)Asthma is a chronic inflammatory disease of the airways. Several candidate genes have been identified with a potential role in the pathogenesis of asthma, including the angiotensin converting enzyme (ACE) gene. We aimed ... -
Cases of Borderline in Vitro Constitutive Thyrotropin Receptor Activity: How to Decide Whether a Thyrotropin Receptor Mutation Is Constitutively Active or Not?
Mueller, Sandra; Gözü, Hülya İliksu; Bircan, Rifat; Jaeschke, Holger; Eszlinger, Markus; Lueblinghoff, Julia; Paschke, Ralf (Mary Ann Liebert, Inc, 2009)Background: Previous in vitro data for several constitutively activating thyrotropin receptor (TSHR) mutations reported divergent results for the constitutive activity of the same mutations. Moreover, several case reports ... -
Effects of confluency, roscovitine and serum starvation on the cell-cycle synchronization and viability of sheep and goat adult fibroblasts
Eren, Aysel; Arat, Sezen; Tuna, Metin; Bircan, Rifat (Elsevier Science Bv, 2014)[No Abstract Available] -
Genetics and phenomics of inherited and sporadic non-autoimmune hyperthyroidism
Gözü, Hülya İliksu; Lueblinghoff, Julia; Bircan, Rifat; Paschke, Ralf (Elsevier Ireland Ltd, 2010)TSH receptor (TSHR) germline mutations occur as activating mutations in familial non-autoimmune hyperthyroidism (FNAH) or sporadic non-autoimmune hyperthyroidism (SNAH). Up to date 17 constitutively activating TSHR mutations ... -
High Prevalence of TSHR/Gs alpha Mutation-negative Clonal Hot Thyroid Nodules (HNs) in a Turkish Cohort
Sancak, Seda; Jaeschke, Holger; Eren, Funda; Özlem, T.; Güllüoğlu, Bahadır; Şen, L. S.; Eszlinger, Markus; Bircan, R. (Georg Thieme Verlag Kg, 2011)Whereas the majority of hot thyroid nodules are caused by somatic TSH-receptor mutations, the percentage of TSH-receptor mutation negative clonal hot nodules (HN) and thus the percentage of hot nodules likely caused by ... -
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?
Gözü, Hülya İliksu; Özçelik, S.; Aloglu, M.; Şahin, A.; Temiz, S.; Dayan, A.; Bircan, Rifat (Funpec-Editora, 2016)The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype ... -
Melatonin reverses the oxidative stress and mitochondrial dysfunction caused by LETM1 silencing
Aral, Cenk; Demirkesen, Seyma; Bircan, Rifat; Yasar Şirin, Duygu (Wiley, 2020)LETM1 is a mitochondrial inner-membrane protein, which is encoded by a gene present in a locus of 4p, which, in turn, is deleted in the Wolf-Hirschhorn Syndrome, and is assumed to be related to its pathogenesis. The cellular ... -
The Mitochondrial DNA Control Region Might Have Useful Diagnostic and Prognostic Biomarkers for Thyroid Tumors
Bircan, Rıfat; Ilıksu Gözü, Hülya; Ulu, Esra; Sarıkaya, Şükran; Gül, Aylin Ege; Şirin, Duygu Yaşar; Aral, Cenk (Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2019)The literature suggests that mitochondrial DNA (mtDNA) defects are associated with a large number of diseases including cancers. The role of mtDNA variations in thyroid cancer is a highly controversial topic. Therefore, ... -
MTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis
Caner, Müge; Bircan, Rifat; Sevinc, Deniz; Benli, Fehime; Guney, A. Ilter; Kurtoglu, Nuri (Soc Brasil Genetica, 2008)Many epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism ... -
A Novel Mutation in the MC2R Gene Causing Familial Glucocorticoid Deficiency Type 1
Akın, Mustafa Ali; Akın, Leyla; Çoban, Dilek; Öztürk, Mehmet Adnan; Bircan, Rıfat; Kurtoğlu, Selim (Karger, 2011)Familial glucocorticoid deficiency (FGD) or hereditary unresponsiveness to adrenocorticotropin (ACTH) is an autosomal recessive disorder characterized by isolated glucocorticoid deficiency associated with normal mineralocorticoid ... -
Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas
Calebiro, Davide; Grassi, Elisa S.; Eszlinger, Markus; Ronchi, Cristina L.; Godbole, Amod; Bathon, Kerstin; Paschke, Ralf; Bircan, Rifat (Amer Soc Clinical Investigation Inc, 2016)Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein alpha subunit (GNAS) are found in approximately 70% of ATAs. The involvement ... -
Shared Sporadic and Somatic Thyrotropin Receptor Mutations Display More Active in Vitro Activities than Familial Thyrotropin Receptor Mutations
Lueblinghoff, Julia; Eszlinger, Markus; Jaeschke, Holger; Mueller, Sandra; Bircan, Rifat; Gözü, Hülya İliksu; Paschke, Ralf (Mary Ann Liebert, Inc, 2011)Background: Germline thyrotropin receptor (TSHR) mutations are associated with sporadic congenital nonautoimmune hyperthyroidism and familial nonautoimmune hyperthyroidism. Somatic TSHR mutations are associated with toxic ... -
siRNA mediated downregulation of LETM1 results in decreased expression of OPA1
Aral, Cenk; Şirin, Duygu Yaşar; Bircan, Rifat (Wiley-Blackwell, 2015)[No Abstract Available] -
Synchronization of fresh and frozen granulosa cells obtained from water buffalo and bovine
Arat, Sezen; Eren, Aysel; Tuna, Metin; Bircan, Rifat (Elsevier Science Bv, 2016)[No Abstract Available]