Kurum Yazarı "Bircan, Rifat" PubMed İndeksli Yayın Koleksiyonu İçin Listeleme
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9 Years Follow-up of a Patient with Pituitary Form of Resistance to Thyroid Hormones (PRTH): Comparison of Two Treatment Periods of D-Thyroxine and Triiodothyroacetic Acid (TRIAC)
Güran, Tülay; Turan, Serap; Bircan, Rifat; Bereket, Abdullah (Walter De Gruyter Gmbh, 2009)Patients with pituitary resistance to thyroid hormones (PRTH) exhibit features of hyperthyroidism due to normal sensitivity to thyroid hormones in some of the peripheral tissues. There is a lack of information in the ... -
Alopecia: Association with Resistance to Thyroid Hormones
Güran, Tülay; Bircan, Rifat; Turan, Serap; Bereket, Abdullah (Freund Publishing House Ltd, 2009)Resistance to thyroid hormone (RTH) syndrome is caused by thyroid hormone beta receptor (TR beta) mutations. Goiter, learning disabilities, psychological abnormalities, sinus tachycardia, hearing deficits, short stature, ... -
Angiotensin Converting Enzyme Gene Polymorphism in Turkish Asthmatic Patients
Eryuksel, Emel; Ceyhan, Berrin Bagci; Bircan, Rifat; Avşar, Melike; Çirakoğlu, Beyazıt (Taylor & Francis Inc, 2009)Asthma is a chronic inflammatory disease of the airways. Several candidate genes have been identified with a potential role in the pathogenesis of asthma, including the angiotensin converting enzyme (ACE) gene. We aimed ... -
BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure
Özçelik, Serhat; Bircan, Rifat; Sarıkaya, Şükran; Gül, Aylin E.; Aydın, Büşra; Özçelik, Melike; Ilıksu Gözü, Hülya (Via Medica, 2019)Introduction: BRAF(V600E) activating mutation is the most frequent genetic abnormality in the pathogenesis of papillary thyroid carcinoma. We aimed to evaluate the association between BRAF(V600E )mutation and well-established ... -
Cases of Borderline in Vitro Constitutive Thyrotropin Receptor Activity: How to Decide Whether a Thyrotropin Receptor Mutation Is Constitutively Active or Not?
Mueller, Sandra; Gözü, Hülya İliksu; Bircan, Rifat; Jaeschke, Holger; Eszlinger, Markus; Lueblinghoff, Julia; Paschke, Ralf (Mary Ann Liebert, Inc, 2009)Background: Previous in vitro data for several constitutively activating thyrotropin receptor (TSHR) mutations reported divergent results for the constitutive activity of the same mutations. Moreover, several case reports ... -
Crimean-Congo hemorrhagic fever virus in tortoises and Hyalomma aegyptium ticks in East Thrace, Turkey: Potential of a cryptic transmission cycle
Kar, Sırrı; Rodriguez, S.E.; Akyıldız, Gürkan; Cajimat, M.N.B.; Bircan, Rifat; Mears, M.C.; Keleş, A.G. (BioMed Central Ltd., 2020)Background: Recent reports have demonstrated the presence of Crimean-Congo hemorrhagic fever virus (CCHFV) genomic material in Hyalomma aegyptium ticks feeding primarily on tortoises belonging to the genus Testudo. This ... -
Genetics and phenomics of inherited and sporadic non-autoimmune hyperthyroidism
Gözü, Hülya İliksu; Lueblinghoff, Julia; Bircan, Rifat; Paschke, Ralf (Elsevier Ireland Ltd, 2010)TSH receptor (TSHR) germline mutations occur as activating mutations in familial non-autoimmune hyperthyroidism (FNAH) or sporadic non-autoimmune hyperthyroidism (SNAH). Up to date 17 constitutively activating TSHR mutations ... -
How Different Methodologies of Harvesting and Analysing the Samples Affect the Test Results in Determining Joint Mediators
Yılmaz, İbrahim; Gökay, Nevzat Selim; Bircan, Rifat; Saraçoğlu Varol, Gamze; Dervişoğlu, Sergülen; Gökçe, Alper (Hindawi Ltd, 2013)Purpose. This study has researched the affect of different methodologies of harvesting and analysing the samples in determining the mediators emerging after the rat articular cartilage injury. Materials and Methods. One ... -
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?
Gözü, Hülya İliksu; Özçelik, S.; Aloglu, M.; Şahin, A.; Temiz, S.; Dayan, A.; Bircan, Rifat (Funpec-Editora, 2016)The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype ... -
Melatonin reverses the oxidative stress and mitochondrial dysfunction caused by LETM1 silencing
Aral, Cenk; Demirkesen, Seyma; Bircan, Rifat; Yasar Şirin, Duygu (Wiley, 2020)LETM1 is a mitochondrial inner-membrane protein, which is encoded by a gene present in a locus of 4p, which, in turn, is deleted in the Wolf-Hirschhorn Syndrome, and is assumed to be related to its pathogenesis. The cellular ... -
Mitochondrial DNA common deletion is not associated with thyroid, breast and colorectal tumors in Turkish patients
Aral, Cenk; Akkiprik, Mustafa; Kaya, Handan; Ataizi-Celikel, Çiğdem; Çaglayan, Sinan; Özışık, Gökhan; Özer, Ayşe (Soc Brasil Genetica, 2010)Recently, efforts have been focused on mitochondrial DNA changes and their relation to human cancers. Among them, a 4977 bp deletion of mitochondrial DNA, named common deletion, has been investigated in several types of ... -
Phylogenetic and phylogeographic analysis of Myrmeleotettix maculatus (Orthoptera: Acrididae: Gomphocerinae) species group in Anatolia
Şirin, Deniz; Taylan, Mehmet Sait; Bircan, Rifat; Akyıldız, Gürkan; Can, Levent (Magnolia Press, 2021)Six Anatolian and one European populations of the Myrmeleotettix maculatus species group, which contains M. maculatus and M. ethicus species, have been studied by using molecular genetics methods with mitochondrial COI ... -
Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas
Calebiro, Davide; Grassi, Elisa S.; Eszlinger, Markus; Ronchi, Cristina L.; Godbole, Amod; Bathon, Kerstin; Paschke, Ralf; Bircan, Rifat (Amer Soc Clinical Investigation Inc, 2016)Autonomous thyroid adenomas (ATAs) are a frequent cause of hyperthyroidism. Mutations in the genes encoding the TSH receptor (TSHR) or the Gs protein alpha subunit (GNAS) are found in approximately 70% of ATAs. The involvement ... -
Sensitive Sequencing Analysis Suggests Thyrotropin Receptor and Guanine Nucleotide-Binding Protein G Subunit Alpha as Sole Driver Mutations in Hot Thyroid Nodules
Stephenson, Alexandra; Eszlinger, Markus; Stewardson, Paul; McIntyre, John B.; Boesenberg, Eileen; Bircan, Rifat; Paschke, Ralf (Mary Ann Liebert, Inc, 2020)Background: Constitutively activating mutations in the thyrotropin receptor (TSHR) and the guanine nucleotide-binding protein G subunit alpha (GNAS) are the primary cause of hot thyroid nodules (HTNs). The reported prevalence ... -
Shared Sporadic and Somatic Thyrotropin Receptor Mutations Display More Active in Vitro Activities than Familial Thyrotropin Receptor Mutations
Lueblinghoff, Julia; Eszlinger, Markus; Jaeschke, Holger; Mueller, Sandra; Bircan, Rifat; Gözü, Hülya İliksu; Paschke, Ralf (Mary Ann Liebert, Inc, 2011)Background: Germline thyrotropin receptor (TSHR) mutations are associated with sporadic congenital nonautoimmune hyperthyroidism and familial nonautoimmune hyperthyroidism. Somatic TSHR mutations are associated with toxic ...