Kurum Yazarı "Akalan, Hande" PubMed İndeksli Yayın Koleksiyonu İçin Listeleme
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Alloreactive memory B cell detection by flow cytometric cross match using polyclonally activated memory B cell culture supernatants
Akalan, Hande; Şirin, Duygu Yaşar; Yılmaz, İpek; Ata, Pınar; Kara, Veli Melih; Taşdemir, Nicel; Bilgen, Türker; Titiz, Mesut İzzet (Elsevier, 2022)In addition to alloantibodies, alloreactive memory B cell (mBC) evaluation has a potential for immunological risk assessment during transplantation processes. For the alloreactive mBCs evaluation currently, direct Flow ... -
Can transcription factors in the intervertebral disc of lopinavir/ritonavir prevent degeneration in the nucleus pulposus by mediating the regulation of inflammation through signaling pathways?
Yılmaz, I.; Akalan, Hande; Karaarslan, N.; Şirin, Duygu Yaşar; Kaplan, N.; Doğan, Mustafa; Özbek, H. (Verduci Publisher, 2022)OBJECTIVE: This study was con-ducted to examine whether lopinavir/ritonavir (Lop/r), an HIV protease inhibitor, can improve disc physiology and slow down intervertebral disc (IVD) degeneration through in vitro experimental ... -
Can transcription factors in the intervertebral disc of lopinavir/ritonavir prevent degeneration in the nucleus pulposus by mediating the regulation of inflammation through signaling pathways?
Yılmaz, İbrahim; Akalan, Hande; Karaarslan, Numan; Şirin, Duygu Yaşar; Kaplan, Nuray; Doğan, Mustafa; Ateş, Oğuz (Verduci Editore s.r.l, 2022)OBJECTIVE: This study was conducted to examine whether lopinavir/ritonavir (Lop/r), an HIV protease inhibitor, can improve disc physiology and slow down intervertebral disc (IVD) degeneration through in vitro experimental ... -
Does oseltamivir protect human chondrocyte and nucleus pulposus cells from degeneration by inhibiting senescence and proinflammation mediated by the NLRP3 inflammasome and NF-kappa B?
Yılmaz, İbrahim; Akalan, Hande; Öznam, K.; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi (Verduci Publisher, 2022)OBJECTIVE: Recent drug design studies suggest that inflammation is among the most important factors in the development of both intervertebral disc (IVD) degeneration (IVDD) and osteoarthritis (OA) due to cartilage damage. ... -
Effects of an acetylcholinesterase inhibitor and an N-methyl-D-aspartate receptor antagonist on inflammation and degeneration of the nucleus pulposus
Yılmaz, İbrahim; Akalan, Hande; Şirin, Duygu Yaşar; Karaarslan, Numan; Kaplan, Nuray; Özbek, Hanefi (Verduci Publisher, 2022)OBJECTIVE: The study aimed to examine the effects of two drugs, an acetylcholinesterase inhibitor (AChEI) and an N-methyl-D-aspartate receptor (NMDAR) antagonist, on degenerated annulus fibrosus (AF) and nucleus pulposus ... -
The effects of rivaroxaban, an oral anticoagulant, on human IVD primary cultures
Çalışkan, Tezcan; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi (Termedia Publishing House Ltd, 2022)Introduction: The present study aimed to investigate the potential effects of rivaroxaban, an oral anticoagulant that inhibits the effects of factor Xa, on intact intervertebral disc tissue cells and the extracellular ... -
Is Favipiravir a Potential Therapeutic Agent in the Treatment of Intervertebral Disc Degeneration by Suppressing Autophagy and Apoptosis?
Yılmaz, İbrahim; Akalan, Hande; Şirin, Duygu Yaşar; Karaarslan, Numan; Özbek, Hanefi; Ateş, Özkan (Turkish Neurosurgical Soc, 2022)AIM: To evaluate the effects of favipiravir (FVP) on cell viability and cytotoxicity in human degenerated primary intervertebral disc (IVD) tissue cell cultures. Furthermore, the protein expressions of hypoxia-inducible ... -
Protective effects of Acetobacter ghanensis against gliadin toxicity in intestinal epithelial cells with immunoregulatory and gluten-digestive properties
Doğuer, Çaglar; Akalan, Hande; Demirok, Nazan Tokatlı; Erdal, Berna; Mete, Rafet; Bilgen, Türker (Springer Heidelberg, 2022)Purpose The aim of this study was to establish whether Acetobacter ghanensis, the probiotic characteristics of which were evaluated previously, attenuates gliadin-induced toxicity in intestinal epithelial cells with ... -
A Study of the Effects of Metformin, a Biguanide Derivative, on Annulus Fibrosus and Nucleus Pulposus Cells
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Akalan, Hande; Özbek, Hanefi (Turkish Neurosurgical Soc, 2020)AIM: To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues. ...