Yazar "Yüksel, Tuğba Nurcan" için PubMed İndeksli Yayın Koleksiyonu listeleme
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Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats
Keskin, Halil; Tavacı, Taha; Halıcı, Hamza; Yüksel, Tuğba Nurcan; Özkaraca, Mustafa; Bilen, Arzu; Halıcı, Zekai (Wiley, 2022)Background A sepsis model was created, induced by cecal ligation and puncture (CLP), in juvenile rat groups. Milrinone (MIL), which is known to have a modulatory effect on pro-inflammatory cytokines, was administered to ... -
The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats
Köse, Duygu; Yüksel, Tuğba Nurcan; Halıcı, Zekai; Çadırcı, Elif; Gürbüz, Muhammed Ali (Aves, 2021)Objective: We designed an experimental model of sepsis in rats to investigate the effects of agomelatine (AGO) on lung tissues using molecular and histopathological methods. Materials and Methods: In our experimental model, ... -
Neuroprotective effect of roflumilast under cerebral ischaemia/reperfusion injury in juvenile rats through NLRP-mediated inflammatory response inhibition
Keskin, Halil; Keskin, Filiz; Tavaci, Taha; Halıcı, Hamza; Yüksel, Tuğba Nurcan; Özkaraca, Mustafa; Halıcı, Zekai (Wiley, 2021)This study aims to investigate the protective effect of roflumilast, a phosphodiesterase (PDE)-4 enzyme inhibitor, and demonstrate its possible role in the development prevention of cerebral ischemia/reperfusion injury ... -
Protective effect of 5-HT7 receptor activation against glutamate-induced neurotoxicity in human neuroblastoma SH-SY5Y cells via antioxidative and antiapoptotic pathways
Yüksel, Tuğba Nurcan; Yayla, Muhammed; Halıcı, Zekai; Çadırcı, Elif; Polat, Beyzagül; Köse, Duygu (Pergamon-Elsevier Science Ltd, 2019)Serotonin exerts anti-inflammatory, antioxidant and antiapoptotic effects through 5-HT7 receptors. The present study determined the role of 5-HT7 receptors in glutamate-induced neurotoxicity by using human SH-SY5Y neuroblastoma ... -
Protective Effects of Idebenone against Sepsis Induced Acute Lung Damage
Akpınar, Erol; Kutlu, Zerrin; Köse, Duygu; Aydın, Pelin; Tavacı, Taha; Bayraktutan, Zafer; Dinçer, Büşra; Yüksel, Tuğba Nurcan (Taylor & Francis Inc, 2022)Background/Aims Sepsis is an uncontrolled systemic infection, withcomplex pathophysiology that may result in acute lung organ damage and cause multiple organ failure. Although much research has been conducted to illuminate ... -
Protective effects of melatonin receptor agonists on endotoxin- induced uveitis in rats
Yüksel, Tuğba Nurcan; Yayla, Muhammed; Köşe, Duygu; Halıcı, Zekai; Bozkurt, Erdinç; Toktay, Erdem (Mashhad Univ Med Sciences, 2023)Objective(s): Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis ...