Yazar "Özbek, Hanefi" için TR-Dizin İndeksli Yayınlar Koleksiyonu listeleme
-
Are Intervertebral Disc Tissue Cells Damaged When Attempting to Prevent Thrombus Formation Using Dabigatran, A New Oral Anticoagulant?
Kaplan, Necati; Karaarslan, Numan; Yılmaz, İbrahim; Yasar Şirin, Duygu; Akgün, Feride Sinem; Çalışkan, Tezcan; Özbek, Hanefi (Turkish Neurosurgical Soc, 2019)AIM: To investigate the effect of dabigatran, a new oral anticoagulant, on human primary cell cultures isolated from intact intervertebral disc tissue. MATERIAL and METHODS: Cell cultures were prepared from tissues obtained ... -
Are Specific Gene Expressions of Extracellular Matrix and Nucleus Pulposus Affected by Primary Cell Cultures Prepared from Intact or Degenerative Intervertebral Disc Tissues?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yasar Şirin, Duygu; Kaplan, Necati; Akyuva, Yener; Ateş, Özkan (Turkish Neurosurgical Soc, 2019)AIM: To determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact tissues. MATERIAL and METHODS: Whereas 12 of the cases were diagnosed with lumbar disc herniation ... -
Delivering Growth Factors through a Polymeric Scaffold to Cell Cultures Containing both Nucleus Pulposus and Annulus Fibrosus
Akyuva, Yener; Kaplan, Necati; Yılmaz, İbrahim; Özbek, Hanefi; Şirin, Duygu Yaşar; Karaarslan, Numan; Ateş, Özkan (Turkish Neurosurgical Soc, 2019)AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth factor 1 (IGF-1)/bone morphogenetic protein (BMP)-2 following intervertebral disc ... -
Does transcription factor, induced by daptomycin and vancomycin, affect HIF-1?, Chondroadherin, and COL2A1?
Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Özbek, Hanefi; Kaya, Yasin Emre; Akyuva, Yener; Doğan, Mustafa; Erdem, İlknur (2018)Aim: In this study, it was firstly aimed to investigate the effect of Daptomycin (DAP) on the proliferation in Vancomycin (VCM)-administered primary chondrocyte cultures and non-drug-administered primary chondrocyte cultures. ... -
Evaluation of inflammatory and biochemical markers in COVID-19 patients treated with tocilizumab alone or with the combination of tocilizumab and convalescent plasma transfusion
Abstract Aim: Macrophage activation syndrome (MAS) develops due to increased expression of systemic pro-inflammatory cytokines in patients with the 2019 novel coronavirus disease (COVID-19). Immune modulators have been ... -
Evaluation of the effect of apixaban on the primary intact intervertebral disc cell cultures
Akgün, Feride Sinem; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Şirin, Duygu Yaşar; Şimşek, Abdullah Talha; Ateş, Özkan (2019)Aim: Apixaban is a frequently preferred pharmacological agent in clinics to prevent deep vein thrombosis and pulmonary embolism.Such new oral anticoagulants may cause hemorrhage’s in tissues and/or organs or may cause ... -
Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue
Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Yasar Şirin, Duygu; Şimşek, Abdullah Talha; Çalışkan, Tezcan; Özbek, Hanefi (Turkish Neurosurgical Soc, 2019)AIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using ... -
Evaluation of the expression and proliferation of degenerative markers in primary cell cultures obtained from human intervertebral disc tissue
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahi?m; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi (2020)Aim: A major cause of low back pain is disc degeneration. Nevertheless, no specific and reliable markers of the degeneration of thenucleus pulposus (NP) are available. This presented study aimed to examine changes in the ... -
In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
Kaya, Yasin Emre; Yılmaz, İbrahi?m; Karaarslan, Numan; Bilir, Bülent; Şirin, Duygu Yaşar; Özbek, Hanefi (2020)Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained ... -
Investigation of the Effects of Methylphenidate, an Amphetamine Derivative, on Intervertebral Disc Tissue Cell Cultures and Matrix Structures
Kaya, Yasin Emre; Karaarslan, Numan; Yasar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Yılmaz, İbrahim (Turkish Neurosurgical Soc, 2019)AIM: To investigate the effects of methylphenidate (MPH), on intervertebral disc tissue (IVD) cell cultures and extracellular matrix structures. Changes in the expression of some important marker genes involved in anabolic ... -
Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Yaman, Onur; Özbek, Hanefi; Ateş, Özkan (2020)AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells ... -
Is Implant Washing and Wound Irrigation with Rifampicin Effective for Preventing Surgical Site Infections in Lumbar Instrumentation?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Öznam, Kadir; Ateş, Özkan; Erdem, İlknur (Turkish Neurosurgical Soc, 2018)AIM: To determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant ... -
Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler
Amaç: Bu çalışmada, dünya genelinde yapılan çalışmalariçerisinde, omurga patolojisinin giderilmesinde araştırılan,moleküler düzeyde gerçekleştirilen hücresel bazlı hedeftedavilerin, sistematik olarak incelenip, konu ... -
A Study of the Effects of Metformin, a Biguanide Derivative, on Annulus Fibrosus and Nucleus Pulposus Cells
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Akalan, Hande; Özbek, Hanefi (Turkish Neurosurgical Soc, 2020)AIM: To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues. ... -
A Study on the Effects of Direct Factor Xa Inhibitors and Direct Thrombin Inhibitors on Human Primary Chondrocyte Cultures
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi; Ateş, Özkan (2019)Aim:This study investigates the effects of two direct factor Xa inhibitors, apixaban and rivaroxaban, and a direct thrombin inhibitor, dabigatran, on human primary chondrocytecultures.Materials and Methods:Monolayer cultured ... -
Systematic Evaluation of Desmopressin Administered to Patients with Aneurysmal Subarachnoid Hemorrhage in the Light of the Literature
Karaarslan, Numan; Yılmaz, İbrahim; Akgün, Feride Sinem; Çalışkan, Tezcan; Özbek, Hanefi; Ateş, Özkan (Turkish Neurosurgical Soc, 2020)AIM: To discuss the management of patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) developing after subarachnoid hemorrhage, in a comparative manner in the light of the literature. MATERIAL ... -
Systematic Evaluation of Promising Clinical Trials-Gene Silencing for the Treatment of Glioblastoma
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Çalışkan, Tezcan; Topuk, Savas; Yasar Şirin, Duygu; Ateş, Özkan (Turkish Neurosurgical Soc, 2019)AIM: To systematically investigate the role of artificial small interfering RNA (SiRNA) molecules in glioblastoma treatment and to give a detailed overview of the literature concerning studies performed in this field ...