Yazar "Yılmaz, İbrahim" için TR-Dizin İndeksli Yayınlar Koleksiyonu listeleme
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Araştırma ve uygulama hastanesine devredilen bir hastanenin yeni doğan ve çocuk yoğun bakım ünitelerindeki antibiyotik sürveyansı ve maliyet değişimi
AMAÇ: Bu çalışmada, Tekirdağ ili ikinci basamakta bulunan yeni doğan ve çocuk yoğun bakım ünitelerinin, üçüncü basamak ile ortak kullanıma devredilme protokolü sonrasındaki antibiyotik kullanım ve maliyet değişimlerini ... -
Are Intervertebral Disc Tissue Cells Damaged When Attempting to Prevent Thrombus Formation Using Dabigatran, A New Oral Anticoagulant?
Kaplan, Necati; Karaarslan, Numan; Yılmaz, İbrahim; Yasar Şirin, Duygu; Akgün, Feride Sinem; Çalışkan, Tezcan; Özbek, Hanefi (Turkish Neurosurgical Soc, 2019)AIM: To investigate the effect of dabigatran, a new oral anticoagulant, on human primary cell cultures isolated from intact intervertebral disc tissue. MATERIAL and METHODS: Cell cultures were prepared from tissues obtained ... -
Are Specific Gene Expressions of Extracellular Matrix and Nucleus Pulposus Affected by Primary Cell Cultures Prepared from Intact or Degenerative Intervertebral Disc Tissues?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yasar Şirin, Duygu; Kaplan, Necati; Akyuva, Yener; Ateş, Özkan (Turkish Neurosurgical Soc, 2019)AIM: To determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact tissues. MATERIAL and METHODS: Whereas 12 of the cases were diagnosed with lumbar disc herniation ... -
Biyopolimerler ile uygulanan lökositten fakir veya lökositten zengin trombositten zengin plazmanın kondrosit proliferasyonunda konvansiyonel trombositten zengin plazma uygulamalarına üstünlüğü var mıdır?
Amaç: Bu çalışmada trombositten zengin plazma (TZP) içeriğindeki lökosit konsantrasyonunun ve TZP'nin ilaç taşıyıcı sistem kullanılarak uygulanmasının in vitro koşullarda kondrosit proliferasyonu üzerine olası etkileri ... -
Çapraz bağlayıcı ve büyüme faktörü emdirilen hidrojel sistemlerinden kontrollü ilaç salımı: Sistematik inceleme
Gökçe, Alper; Yılmaz, İbrahim; Tonbul, Murat; Gökay, Nevzat Selim; Bircan, Rifat; Gökçe, Çiğdem (2012)Amaç: Bu çalışmada, dünya genelinde son 31 yılda yapılan çalışmalar içerisinde, kontrollü ilaç taşıma sistemi olan ve çapraz bağlayıcı ilavesi ile biodegradasyona uğratılmış büyüme faktörü emdirilen hidrojelin, kıkırdak ... -
Delivering Growth Factors through a Polymeric Scaffold to Cell Cultures Containing both Nucleus Pulposus and Annulus Fibrosus
Akyuva, Yener; Kaplan, Necati; Yılmaz, İbrahim; Özbek, Hanefi; Şirin, Duygu Yaşar; Karaarslan, Numan; Ateş, Özkan (Turkish Neurosurgical Soc, 2019)AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth factor 1 (IGF-1)/bone morphogenetic protein (BMP)-2 following intervertebral disc ... -
Do we damage nucleus pulposus tissue while treating cerebrovascular ischemic neurological deficits with nimodipine?
Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Baykız, Derya; Demirkiran, Aykut; Ateş, Özkan (2018)Aim: Nimodipine is used to prevent cerebrovascular-originated ischemic neurological deficits, yet its effects on nucleus pulposus (NP) cells or annulus fibrosus (AF) cells weren’t studied. This study aimed to examine ... -
Does insulin, transferrin and selenous acid preparation effect chondrocyte proliferation?
Gökçe, Alper; Yılmaz, İbrahim; Gökay, Nevzat Selim; Can, Levent; Gökçe, Çiğdem (Turkish Assoc Orthopaedics Traumatology, 2014)Objective: The aim of this study was to test the hypothesis that insulin, human transferrin, and selenous acid (ITS) preparation have positive effects on chondrocyte proliferation and morphology and investigate the biochemical ... -
Does transcription factor, induced by daptomycin and vancomycin, affect HIF-1?, Chondroadherin, and COL2A1?
Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Özbek, Hanefi; Kaya, Yasin Emre; Akyuva, Yener; Doğan, Mustafa; Erdem, İlknur (2018)Aim: In this study, it was firstly aimed to investigate the effect of Daptomycin (DAP) on the proliferation in Vancomycin (VCM)-administered primary chondrocyte cultures and non-drug-administered primary chondrocyte cultures. ... -
The Effects of NLR on the Diagnosis and Pharmacological Management of Brain Abscesses
Çalışkan, Tezcan; Yılmaz, İbrahim; Hacıoğlu Kasım, Fatma Bahar; Ersöz, Emel; Doğan, Mustafa; Karaarslan, Numan (2021)Aim: The present study aims to examine the effectiveness of the neutrophil-tolymphocyte ratio in the treatment and diagnosis of patients with brain abscesses. Methods: In this retrospective study, radiological, neurological, ... -
Evaluation of Empirical Antibiotic Treatment in Culture Negative Pyogenic Vertebral Osteomyelitis
Doğan, Mustafa; Şimşek, Abdullah Talha; Yılmaz, İbrahim; Karaarslan, Numan (Turkish Neurosurgical Soc, 2019)AIM: To investigate the efficacy of empirical antibiotic treatment in culture-negative pyogenic vertebral osteomyelitis (PVO) cases. MATERIAL and METHODS: The records of patients with culture-negative PVO who were treated ... -
Evaluation of inflammatory and biochemical markers in COVID-19 patients treated with tocilizumab alone or with the combination of tocilizumab and convalescent plasma transfusion
Abstract Aim: Macrophage activation syndrome (MAS) develops due to increased expression of systemic pro-inflammatory cytokines in patients with the 2019 novel coronavirus disease (COVID-19). Immune modulators have been ... -
Evaluation of neutrophil-to-lymphocyte ratio as a marker of inflammatory response in spondylodiscitis
Karaarslan, Numan; Yılmaz, İbrahim; Akgün, Feride Sinem; Çalışkan, Tezcan; Doğan, Mustafa; Bilir, Bülent; Ateş, Özkan (2018)Aim: Spondylodiscitis, if not diagnosed on time, can cause morbidity or mortality at high rates. This study was carried out with the aim of testing the hypothesis that “neutrophil-to-lymphocyte ratio can be used” especially ... -
Evaluation of the effect of apixaban on the primary intact intervertebral disc cell cultures
Akgün, Feride Sinem; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Şirin, Duygu Yaşar; Şimşek, Abdullah Talha; Ateş, Özkan (2019)Aim: Apixaban is a frequently preferred pharmacological agent in clinics to prevent deep vein thrombosis and pulmonary embolism.Such new oral anticoagulants may cause hemorrhage’s in tissues and/or organs or may cause ... -
Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue
Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Yasar Şirin, Duygu; Şimşek, Abdullah Talha; Çalışkan, Tezcan; Özbek, Hanefi (Turkish Neurosurgical Soc, 2019)AIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using ... -
Investigation of the Effects of Methylphenidate, an Amphetamine Derivative, on Intervertebral Disc Tissue Cell Cultures and Matrix Structures
Kaya, Yasin Emre; Karaarslan, Numan; Yasar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Yılmaz, İbrahim (Turkish Neurosurgical Soc, 2019)AIM: To investigate the effects of methylphenidate (MPH), on intervertebral disc tissue (IVD) cell cultures and extracellular matrix structures. Changes in the expression of some important marker genes involved in anabolic ... -
Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Yaman, Onur; Özbek, Hanefi; Ateş, Özkan (2020)AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells ... -
Is Implant Washing and Wound Irrigation with Rifampicin Effective for Preventing Surgical Site Infections in Lumbar Instrumentation?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Öznam, Kadir; Ateş, Özkan; Erdem, İlknur (Turkish Neurosurgical Soc, 2018)AIM: To determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant ... -
İki Farklı Hastanenin Ortopedi Kliniklerinde Kullanılan Antibiyotik Seçeneklerinin Akılcı Antibiyotik Kullanımı Açısından Değerlendirilmesi
İşyar, Mehmet; Doğan, Mustafa; Gümüştaş, Seyit Ali; Yılmaz, İbrahim; Bilir, Bülent; Güler, Olcay; Mahiroğulları, Mahir; Saraçoğlu Varol, Gamze (2016)Amaç: Birbirine yakın ve aynı bölgede yer alan iki farklı hastanenin ortopedi ve travmatoloji servislerinde yatan hastalarda, etkeni saptanan enfeksiyon olgularında antibiyotik kullanımının, akılcı ilaç tedavi rehberleri ... -
Ortopedik Cerrah Tirotoksik Fırtınaya Yakalanmamak İçin Ne Yapmalı?
Bilir, Betül Ekiz; Bilir, Bülent; İşyar, Mehmet; Tonbul, Ayşe Tuba; Öznam, Kadir; Yılmaz, İbrahim; Çakmak, Selami (2016)Amaç: Non iyonik kontrast maddeler gibi iyot içeren preparatların kullanıldığı görüntüleme tetkiklerinde, kas protein yıkımına neden olan travmalarda, kosta kırıklarında, pürülan artrit gibi enfektif olgularda, kalça ...