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An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer's disease
(Ios Press, 2008)
Acquired disturbances of several aspects of cellular metabolism appear pathologically important in sporadic Alzheimer's disease (SAD). Among these, brain glucose utilization is reduced in the early stages of the disease. ...
Unraveling the molecular mechanisms behind the metabolic basis of sporadic alzheimer's disease
(IOS Press, 2009)
Peripheral insulin resistance is associated with hyperinsulinemia, which may be associated with brain insulin deficiency that is characteristic of sporadic Alzheimer's disease (sAD). Oxidative insult, which is the result ...