Kurum Yazarı "Kandemir, Hakan" Fakülteler İçin Listeleme
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Synthesis of dipyrrolo[2,3-a:1 ',2 ',3 '-fg]acridin-12(1H)-ones
Beyer, Renee L.; Kandemir, Hakan; Bhadbhade, Mohan; Şengül, İbrahim Fazıl; Leu, Chao-Wei; Wenholz, Daniel S.; Black, David StC. (Pergamon-Elsevier Science Ltd, 2018)Acylation reactions of 4,6-dimethoxyindoles with glyoxyloyl chlorides were achieved by the use of graphite powder in 1,2-dichloroethane at reflux. The products were monoketones as a result of decarbonylation, rather than ... -
Synthesis of Imine and Amine-Linked Macrocycles Containing Tris-Indoles
Kandemir, Hakan; Şengül, İbrahim Fazıl; Kumar, Naresh; Black, David StC. (Csiro Publishing, 2017)The synthesis of 21-membered imine-and amine-linked tris-indole macrocycles starting from 7-nitroethylindoles is described. The 7-nitroethylindoles are converted to 2,2'-diindolylmethanes and the nitro groups reduced to ... -
Synthesis of indole-2-carbohydrazides and 2-(indol-2-yl)-1,3,4-oxadiazoles as antioxidants and their acetylcholinesterase inhibition properties
Bingül, Murat; Sağlam, Mehmet Turgut; Kandemir, Hakan; Boga, Mehmet; Şengül, İbrahim Fazıl (Springer Wien, 2019)A range of novel 4,6-dimethoxy-1H-indole-2-carbohydrazides was prepared starting from methyl 4,6-dimethoxy-1H-indole-2-carboxylate which underwent cyclodehydration to generate the corresponding 2-(indol-2-yl)-1,3,4-oxadiazole ... -
Synthesis of Methylene Bridged Bis-pyrrolo[3,2-c]carbazoles via an Unusual Vilsmeier-Haack Product of N-Ethylcarbazole
Kandemir, Hakan; Sağlam, Mehmet Turgut; Şengül, İbrahim Fazıl (Taylor & Francis Ltd, 2020)The unexpected result for the formylation of N-ethylcarbazole under the Vilsmeier-Haack conditions (POCl3/DMF) led to the synthesis of novel methylene bridged bis-pyrrolo[3,2-c]carbazoles via Hemetsberger indole synthesis ... -
Synthesis of Novel Pyrrolo[3,2-c]carbazole and Dipyrrolo[3,2-c: 2 ',3 '-g]carbazole Derivatives
Şengül, İbrahim Fazıl; Astarcı, Erhan; Kandemir, Hakan (Georg Thieme Verlag Kg, 2016)Pyrrolocarbazole and dipyrrolocarbazoles have been synthesized via the Hemetsberger indole synthesis, starting from 9-ethyl carbazole-3-carbaldehyde and 9-ethylcarbazole-3,6-dicarbaldeyde, respectively. The pyrrolocarbazole ... -
Synthesis of pyrrolo[3,2-c]carbazole-2-carbohydrazides and pyrrolo[3,2-c]carbazol-2-yl-1,3,4-oxadiazoles and their in vitro antibacterial evaluation
Sağlam, Mehmet Turgut; Gündogdu, Aycan; Hora, Mehmet; Kandemir, Hakan; Şengül, İbrahim Fazıl (Taylor and Francis Ltd., 2021)A number of novel pyrrolo[3,2-c]carbazole-2-carbohydrazides 5a–d was prepared from readily available 6-methyl-1,6-dihydropyrrolo[3,2-c]carbazole-2-carboxylate 3 and underwent cyclodehydration to produce the corresponding ... -
Synthesis, characterization, UV-Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systems
Sağlam, Mehmet Turgut; Bingül, Murat; Şenkuytu, Elif; Boğa, Mehmet; Zorlu, Yunus; Kandemir, Hakan; Şengül, İbrahim Fazıl (Elsevier, 2020)A number of bis-indolyl imine helical structures has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole with different o-phenyl diamines as pi-spacer ... -
Synthesis, photophysical and antioxidant properties of carbazole-based bis-thiosemicarbazones
Bingül, Murat; Şenkuytu, Elif; Sağlam, Mehmet Turgut; Boga, Mehmet; Kandemir, Hakan; Şengül, İbrahim Fazıl (Springer, 2019)Utilizing Schiff base condensation of the 9-ethylcarbazole-3,6-dicarbaldehyde and thiosemicarbazides, four new N-ethylcarbazole-based bis-thiosemicarbazone compounds 4a-d were successfully synthesized in high yields. The ... -
Synthesis, photophysical and antioxidant properties of pyrrolo[3,2-c]carbazole and dipyrrolo[3,2-c:2,3-g]carbazole compounds
Bingül, Murat; Şenkuytu, Elif; Boga, Mehmet; Uslu, Tugce Nur; Kandemir, Hakan; Şengül, İbrahim Fazıl (Springer, 2019)The synthesis of (6-ethyl-1,6-dihydropyrrolo[3,2-c]carbazol-2-yl)methanol 5 and (6-ethyl-6,11-dihydro-1H-dipyrrolo[3,2-c:2,3-g]carbazole-2,10-diyl)dimethanol 6 were achieved via the reduction of methyl pyrrolo carbazole ... -
Synthesis, Reactivity and Biological Properties of Methoxy-Activated Indoles
Şengül, İbrahim Fazıl; Bingül, Murat; Kandemir, Hakan; Kumar, Naresh; Black, David StC. (Societa Chimica Italiana, 2021)Indoles continue to play a central role in the development of new structures of chemical and biological interest. They are the source of numerous biologically active natural products by virtue of their derivation from ... -
Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth in Vivo
Cömert Önder, F.; Kahraman, N.; Bellur Atıcı, E.; Cagır, A.; Kandemir, Hakan; Tatar, G.; Özpolat, Bülent (American Chemical Society, 2021)Eukaryotic elongation factor 2 kinase (eEF-2K) is an unusual alpha kinase involved in protein synthesis through phosphorylation of elongation factor 2 (EF2). eEF-2K is highly overexpressed in breast cancer, and its activity ...