Yazar "Kandemir, Hakan" için Fakülteler listeleme
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Azaindole-BODIPYs: Synthesis, fluorescent recognition of hydrogen sulfate anion and biological evaluation
Kesan, Gurkan; Topaloglu, Burcu; Özcan, Emrah; Kazan, Hasan Huseyin; Ecik, Esra Tanriverdi; Şenkuytu, Elif; Cosut, Bunyemin; Kandemir, Hakan (Pergamon-Elsevier Science Ltd, 2019)The synthesized and sensing capability of two novel azaindole substituted mono and distyryl BODIPY dyes against bisulfate anion were reported. Structural characterizations of the targeted compounds were conducted by using ... -
Carbazole substituted BODIPY dyes: Synthesis, photophysical properties and antitumor activity
Şengül, İbrahim Fazıl; Okutan, Elif; Kandemir, Hakan; Astarcı, Erhan; Çoşut, Bünyemin (Elsevier Sci Ltd, 2015)In this study, two different BODIPYs containing carbazole groups at the mesa position were designed and synthesized. All compounds were fully characterized by elemental analysis, FT-IR, matrix-assisted laser desorption/ionization ... -
Dimethoxyindoles based thiosemicarbazones as multi-target agents; synthesis, crystal interactions, biological activity and molecular modeling
Yıldız, Minhal; Bingül, Murat; Zorlu, Yunus; Sağlam, Mehmet F.; Boğa, Mehmet; Temel, Mutesir; Şengül, İbrahim F.; Kandemir, Hakan (Academic Press Inc Elsevier Science, 2022)Alzheimer's disease (AD) is known as one of the most devastating neurodegenerative disease diagnosed for the old-aged people and cholinesterase inhibitors (ChEI) can be used as an effective palliative treatment for AD. A ... -
Experimental and theoretical studies of carbazole-based Schiff base as a fluorescent Fe3+ probe
Kandemir, Hakan; Koçak, Abdulkadir; Tumay, Süreyya Oguz; Cosut, Bunyemin; Zorlu, Yunus; Şengül, İbrahim Fazıl (Scientific Technical Research Council Turkey-Tubitak, 2018)Synthesis of a new (E)-N1-((9-ethyl-9H-carbazol-3-yl)methylene)-5-nitrobenzene-1,2-diamine as a fluorescent chemosensor for selective detection of Fe3+ ion over a number of other metal ions is described. The method for the ... -
Facile Synthesis of Some 3-(Benzimidazol-2-yl)- and 3,6-Di(Benzimidazol-2-yl)-9-ethyl-9H-carbazoles
Kandemir, Hakan; Şengül, İbrahim Fazıl (Taylor & Francis Inc, 2015)A simple and efficient synthesis of novel 3-(benzimidazol-2-yl)- and 3,6-di(benzimidazol-2-yl)-9-ethyl-9H-carbazoles is described. The synthetic approach for the preparation of 2-substituted benzimidazoles 4-8 and ... -
Investigation of spectroscopic properties of mono and Di-styryl indole-containing BODIPYs
Topaloğlu Aksoy, B.; Erol, İsmail; Kandemir, Hakan; Sağlam, Mehmet F.; Şengül, I.F.; Çoşut, B. (Elsevier B.V., 2023)In the current study, two novel mono- and distyryl BODIPYs have been successfully synthesized employing the Knoevenagel type condensation reaction between 1,3,5,7?tetramethyl BODIPY and 2,3-diphenyl-4,6-dimethoxyindole-7 ... -
Light harvesting systems composed of carbazole based subphthalocyanine-BODIPY enhanced with intramolecular fluorescence resonance energy transfer (FRET)
Ecik, Esra Tanriverdi; Özcan, Emrah; Kandemir, Hakan; Şengül, İbrahim Fazıl; Cosut, Bunyemin (Elsevier Sci Ltd, 2017)A new series of subphthalocyanine-borondipyrromethene scaffolds containing N-ethylcarbazole moiety have been successfully designed and synthesized. The identities of synthesized compounds were confirmed by using H-1, C-13 ... -
Meso-piperidine linked bodipys: Synthesis, fluorescent properties and biological evaluation
Ecik, Esra Tanriverdi; Kazan, Hasan Huseyin; Şengül, İbrahim Fazıl; Kandemir, Hakan; Cosut, Bunyemin (Elsevier Science Bv, 2019)The synthesis and characterization of meso-piperidine linked Bodipy starting from 4-(2-(piperidine-1-yl)ethoxy) benzaldehyde was described. Meso-piperidine linked Bodipy was subsequently used for the construction of ... -
Methoxy-activated indole-7-carbohydrazides; synthesis, antioxidant, and anticancer properties
Kandemir, Hakan; Izgi, Samet; Çınar, İrfan; Cebeci, Fatma; Dirican, Ebubekir; Sağlam, Mehmet F.; Şengül, İbrahim F. (Wiley, 2022)Indole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole-7-carbohydrazides has been successfully ... -
Naked-eye fluorescent sensor for Cu(II) based on indole conjugate BODIPY dye
Oğuz Tümay, Süreyya; Okutan, Elif; Şengül, İbrahim Fazıl; Özcan, Emrah; Kandemir, Hakan; Doruk, Tuğrul; Çoşut, Bünyemin (Pergamon-Elsevier Science Ltd, 2016)A novel on/off fluorescent indole/BODIPY-based Cu2+ chemosensor (3) was synthesized by Knoevenagel condensation of BODIPY derivative 1 with 2-methyl-indole-3-carbaldehyde 2. The identity of compound 3 was confirmed by H-1 ... -
Novel carbazole containing zinc phthalocyanine photosensitizers: Synthesis, characterization, photophysicochemical properties and in vitro study
Göksel, Meltem; Şengül, İbrahim Fazıl; Kandemir, Hakan; Durmuş, Mahmut (World Sci Publ Co Inc, 2016)Tetra and octa substituted novel zinc(II) phthalocyanines (3a and 5a) bearing carbazole groups were synthesized by cyclotetramerization of respective phthalonitrile derivatives (3 and 5). The zinc(II) phthalocyanines (3a ... -
Novel inhibitors of eukaryotic elongation factor 2 kinase: in silico, synthesis and in vitro studies
Önder, F.C.; Durdağı, S.; Kahraman, N.; Uslu, T.N.; Kandemir, Hakan; Atıcı, E.B.; Ay, M. (Academic Press Inc., 2021)Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual alpha kinase whose expression is highly upregulated in various cancers and contributes to tumor growth, metastasis, and progression. More importantly, eEF2K ... -
Some electrophilic reactivity studies of di-(2-indolyl)dibenzofurans and di-(2-indolyl)carbazoles
Şengül, İbrahim Fazıl; Somphol, Kittiya; Kandemir, Hakan; Kumar, Naresh; Black, David StC. (Pergamon-Elsevier Science Ltd, 2014)3,6-Bis-(2-indolyl)dibenzofurans 1,2, and carbazoles 3-6 underwent a range of electrophilic substitution reactions to produce formyl indoles 7-12, biindolyls 24-28 and 33-34, glyoxylamides 40-42, and amides 48. (C) 2014 ... -
Substituent effects in solid-state assembly of activated benzotriazoles
Wenholz, Daniel S.; Bhadbhade, Mohan; Kandemir, Hakan; Ho, Junming; Kumar, Naresh; Black, David StC. (Royal Soc Chemistry, 2019)Aromatic donor-acceptor stacking involving electron-rich -donors and electron-deficient -acceptors has been utilized in a broad spectrum of diverse applications to great effect. We report the discovery of unprecedented ... -
Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formation
Mielczarek, Marcin; Thomas, Ruth V.; Ma, Cong; Kandemir, Hakan; Yang, Xiao; Bhadbhade, Mohan; Kumar, Naresh (Pergamon-Elsevier Science Ltd, 2015)Our ongoing research focused on targeting transcription initiation in bacteria has resulted in synthesis of several classes of mono-indole and mono-benzofuran inhibitors that targeted the essential protein-protein interaction ... -
Synthesis and biological evaluation of 2,5-di(7-indolyl)-1,3, 4-oxadiazoles, and 2-and 7-indolyl 2-(1,3,4-thiadiazolyl)ketones as antimicrobials
Kandemir, Hakan; Ma, Cong; Kutty, Samuel K.; Black, David StC.; Griffith, Renate; Lewis, Peter J.; Kumar, Naresh (Pergamon-Elsevier Science Ltd, 2014)A range of novel hydrazine bridged bis-indoles was prepared from readily available indole-7-glyoxyloylchlorides and 7-trichloroacetylindoles and underwent cyclodehydration to produce 2,5-di(7-indolyl)-1,3,4-oxadiazoles and ... -
Synthesis of 7,7 '-Linked-Bis-Indoles Via 7-Tryptamines
Kandemir, Hakan; Şengül, İbrahim Fazıl; Gardner, Christopher R.; Werry, Eryn L.; Barron, Melissa L.; Kassiou, Michael; Black, David StC. (Pergamon-Elsevier Science Ltd, 2016)The synthesis of 7-tryptamines was accomplished via the reduction of 7-nitrovinylindoles which were developed by the condensation of indole-7-carbaldehydes with nitromethane and ammonium acetate. 7-Tryptamines were ... -
Synthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, α-glucosidase inhibition properties and docking study
İzgi, S.; Şengül, İbrahim Fazıl; Şahin, E.; Koca, M.S.; Cebeci, F.; Kandemir, Hakan (Elsevier B.V., 2022)In this current work, 7-azaindole based 1,3,4-oxadiazoles have been successfully prepared by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic anhydrides to give the corresponding ... -
Synthesis of a 7-(aminomethyl)indole and related bis-indole derivatives
Kandemir, Hakan; Şengül, İbrahim Fazıl; Kumar, Naresh; Black, David StC. (Arkat Usa Inc, 2016)A 7-(aminomethyl) indole is a useful precursor to form a new range of unsymmetrical and symmetrical 3-substituted amide-, imine-, and amine-linked 7,7'-bis-indoles. The reduction of an imine linked bis-indole leads to ... -
Synthesis of a novel N,N ',N '-tetraacetyl-4,6-dimethoxyindole-based dual chemosensor for the recognition of Fe3+ and Cu2+ ions
Şenkuytu, Elif; Bingül, Murat; Sağlam, Mehmet Turgut; Kandemir, Hakan; Şengül, İbrahim Fazıl (Elsevier Science Sa, 2019)A novel N,N'N',1-tetraacetyl-4,6-dimethoxy-1H-indole-2-carbohydrazide 5, bearing four N-acetyl groups (N-COCH3) as cation binding sites was successfully synthesized by the reaction of readily available 4,6-dimethoxy-1H-i ...