Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities
dc.contributor.author | Türkyılmaz, Murat | |
dc.contributor.author | Dönmez, Murat | |
dc.contributor.author | Ateş, Murat | |
dc.date.accessioned | 2023-04-20T08:08:34Z | |
dc.date.available | 2023-04-20T08:08:34Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2458-973X | |
dc.identifier.uri | https://doi.org/10.47481/jscmt.1117139 | |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/533168 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/11350 | |
dc.description.abstract | In this study, theophylline (1) compounds were synthesized with addition of 2-bromoetha-nol, 2-bromoacetamide and methyl-2-bromoacetate to attain symmetric connections to NHCs (2a–c). New complexes containing the symmetric N-heterocyclic carbene (NHC) ligands were synthesized using azolium salts in dimethyl formamide (DMF). After the NHC predecessor compounds reacted with Ag2O, Ag(I)-NHC complexes were synthesized in the following: 7,9-di-(2-hydroxyethyl)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dionedium silver(I)bromide (3a), 7,9-di(acetamide)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-di-ondium silver(I)bromide (3b) and 7,9-di(methylacetate)-8,9-dihydro-1,3-dimethyl-1H-pu-rine-2,6(3H,7H)-diondiumsilver(I)bromide (3c). Both synthesized NHC predecessors (2a-c) and Ag(I)-NHC complexes (3a-c) were described by FTIR, 1H-NMR, 13C-NMR, liquid and solid-state conductivity values, TGA analysis, melting point analysis and XRD spectroscopy. In-vitro antibacterial activities of NHC-predecessors and Ag(I)-NHC complexes were tested against gram-positive bacteria (Staphylococcus Aureus and Bacillus Cereus), gram-negative bacteria (Escherichia Coli and Listeria Monocytogenes), and fungus (Candida Albicans) in Tryptic Soy Broth method. Ag(I)-NHC complexes showed higher antibacterial activity than pure NHC predecessors. The lowest microbial inhibition concentration (MIC) value of compound 3a was obtained as 11.56 ?g/ml for Escherichia Coli and 11.52 ?g/ml for Staphylococcus Aureus. All tested complexes displayed antimicrobial activity with different results. | en_US |
dc.language.iso | eng | en_US |
dc.identifier.doi | 10.47481/jscmt.1117139 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | SEM analysis. | en_US |
dc.subject | Candida Albicans | en_US |
dc.subject | theophylline | en_US |
dc.subject | Antimicrobial activity | en_US |
dc.title | Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of sustainable construction materials and technologies (Online) | en_US |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Coğrafya Bölümü | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 53 | en_US |
dc.identifier.endpage | 61 | en_US |
dc.institutionauthor | Türkyılmaz, Murat | |
dc.institutionauthor | Dönmez, Murat | |
dc.institutionauthor | Ateş, Murat | |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.trdizinid | 533168 | en_US |
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