dc.contributor.author | Çelikkol, Aliye | |
dc.contributor.author | Doğan, Mustafa | |
dc.contributor.author | Güzel, Eda Çelik | |
dc.contributor.author | Erdal, Berna | |
dc.contributor.author | Yılmaz, A. | |
dc.date.accessioned | 2023-04-20T08:04:16Z | |
dc.date.available | 2023-04-20T08:04:16Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1119-3077 | |
dc.identifier.uri | https://doi.org/10.4103/njcp.njcp-1633-21 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/11064 | |
dc.description.abstract | Background: In coronavirus disease 2019 (COVID-19) caused by SARSCoV2 viruses, coagulation abnormalities are strongly correlated between disease severity and mortality risk. Aims: The aim was to search for new indices to determine mortality risk. Fibrinogen times D-dimer to albumin times platelet ratio calculated with the formula (FDAPR index: ((Fibrinogen × D-dimer)/(Albumin × Platelet)) investigated as a mortality marker in COVID-19 patients. The hospitalization data of 1124 patients were analyzed from the electronic archive system. Hemogram, coagulation, and inflammatory markers were investigated in the study group. Materials and Methods: All statistical analyses like the student t-test, Mann-Whitney U, Kaplan-Meier, and Cox hazard ratio, were performed with the SPSS 22.0 program. Results: Prothrombin time was prolonged significantly in patients (P < 0.05) compared to healthy subjects (n = 30). D-dimer and fibrinogen were high, and albumin and platelet counts were low in COVID-19 patients (all, P < 0.001). When the data of 224 non-survivors and 900 survived patients were compared, D-dimer and fibrinogen were higher, and albumin and platelet lower (all, P < 0.001) compared to mild and severe patients. At the cut-off value of 0.49, the FDAPR index was performed with 89.1% sensitivity and 88.6% specificity. FDAPR index had the highest mortality predictive power (P < 0.01; HR = 5.366; 95% CI; 1.729-16.654). Conclusions: This study revealed that the FDAPR index could be used as a mortality marker of COVID-19 disease. © 2022 Wolters Kluwer Medknow Publications. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.identifier.doi | 10.4103/njcp.njcp-1633-21 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Biomarker | en_US |
dc.subject | coagulation | en_US |
dc.subject | D-dimer | en_US |
dc.subject | mortality | en_US |
dc.subject | SARS-CoV2 | en_US |
dc.subject | albuminoid | en_US |
dc.subject | biological marker | en_US |
dc.subject | fibrin degradation product | en_US |
dc.subject | fibrin fragment D | en_US |
dc.subject | fibrinogen | en_US |
dc.subject | hemostatic agent | en_US |
dc.subject | virus RNA | en_US |
dc.subject | human | en_US |
dc.subject | retrospective study | en_US |
dc.subject | Albumins | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Fibrin Fibrinogen Degradation Products | en_US |
dc.subject | Fibrinogen | en_US |
dc.subject | Hemostatics | en_US |
dc.subject | Humans | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | RNA, Viral | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | A novel combined index of D-dimer, fibrinogen, albumin, and platelet (FDAPR) as mortality predictor of COVID-19 | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Nigerian Journal of Clinical Practice | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 1418 | en_US |
dc.identifier.endpage | 1423 | en_US |
dc.institutionauthor | Çelikkol, Aliye | |
dc.institutionauthor | Doğan, Mustafa | |
dc.institutionauthor | Güzel, Eda Çelik | |
dc.institutionauthor | Erdal, Berna | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57218879837 | |
dc.authorscopusid | 57196589837 | |
dc.authorscopusid | 57489787300 | |
dc.authorscopusid | 24483063300 | |
dc.authorscopusid | 57197367730 | |
dc.identifier.scopus | 2-s2.0-85138472032 | en_US |
dc.identifier.pmid | 36149199 | en_US |