ORCID "0000-0001-5848-3680" için listeleme
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Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats
Utkan, Tijen; Göçmez, Semil Selcen; Regunathan, Soundararajan; Arıcıoğlu, Feyza (Pergamon-Elsevier Science Ltd, 2012)Agmatine (1-amino-4-guanidino-butane), a metabolite of L-arginine through the action of arginine decarboxylase, is a novel neurotransmitter. In the present study, effects of agmatine on cognitive functions have been evaluated ... -
Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats
Gacar, Nejat; Mutlu, Oğuz; Utkan, Tijen; Çelikyurt, İpek Komşuoğlu; Göçmez, Semil Selcen; Ulak, Guner (Pergamon-Elsevier Science Ltd, 2011)Resveratrol (3,5,4-trihydroxy-trans-stilbene), which is found in grapes and red wine has been shown to protect neuronal cells with its antioxidant activity, improve memory function in dementia and reverse acetylcholine ... -
Chronic administration of fluoxetine impairs neurogenic and endothelium-dependent relaxation of the rabbit corpus cavernosum smooth muscle
Göçmez, Semil Selcen; Utkan, Tijen; Gacar, Nejat; Sarıoğlu, Yusuf (Elsevier, 2011)Antidepressants, including selective serotonin reuptake inhibitors (SSRIs), cause erectile dysfunction: however, the mechanism by which they cause erectile function is unclear. We investigated the reactivity of the corpus ... -
Chronic administration of imipramine but not agomelatine and moclobemide affects the nitrergic relaxation of rabbit corpus cavernosum smooth muscle
Göçmez, Semil Selcen; Utkan, Tijen; Gacar, Nejat (Elsevier, 2013)Sexual dysfunction is a common and underestimated effect of antidepressants. However, the mechanism by which these drugs cause erectile dysfunction is unclear. We investigated the reactivity of the corpus cavernosum of ... -
Chronic moderate alcohol consumption induces iNOS expression in the penis: An immunohistochemical study
Gonca, Suheyla; Yazir, Yusufhan; Göcmez, Semil Selcan; Dalcık, Ekim Nur; Utkan, Tijen; Dalcık, Hakki (Tubitak Scientific & Technical Research Council Turkey, 2014)Aim: To investigate the effect of moderate alcohol consumption on metabolic alterations, inducible nitric oxide synthase (iNOS), immunohistochemical distribution, and morphological damage to penile erectile tissue in rats. ... -
The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazole on spatial learning and memory in rats
Göçmez, Semil Selcen; Yazir, Yusufhan; Şahin, Deniz; Karadenizli, Sabriye; Utkan, Tijen (Pergamon-Elsevier Science Ltd, 2015)Since the discovery of nitric oxide (NO) as a neuronal messenger, its way to modulate learning and memory functions is subject of intense research. NO is an intercellular messenger in the central nervous system and is ... -
Effect of harmane, an endogenous beta-carboline, on learning and memory in rats
Çelikyurt, İpek Komşuoğlu; Utkan, Tijen; Göçmez, Semil Selcen; Hudson, Alan; Arıcıoğlu, Feyza (Pergamon-Elsevier Science Ltd, 2013)Our aim was to investigate the effects of acute harmane administration upon learning and memory performance of rats using the three-panel runway paradigm and passive avoidance test. Male rats received harmane (2.5, 5, and ... -
Effects of chronic low- and high-dose ethanol intake on the nitrergic relaxations of corpus cavernosum and penile nitric oxide synthase in the rabbit
Yazır, Y.; Göçmez, Semil Selcen; Utkan, Tijen; Komşuoğlu Çelikyurt, I.; Gacar, Nejat; Sarıoğlu, Y. (Nature Publishing Group, 2012)Epidemiological evidence showed that chronic ethanol consumption is a major risk factor in the development of impotence. The present study investigated the effects of carbachol-, electrical field stimulation (EFS)-, sodium ... -
Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats
Komsuoglu-Çelikyurt, Ipek; Göçmez, Semil Selcen; Mutlu, Oğuz; Gacar, Nejat; Arıcıoğlu, Feyza; Utkan, Tijen (Pergamon-Elsevier Science Ltd, 2011)Aims: The influence of 3-bromo-7-nitroindazole (3-Br 7-NI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor, and [1H-[1,2,4]-oxadiazole[4,3a]-quinoxaline-1-one] (ODQ), a highly selective, irreversible ... -
Selective and nonselective neuronal NOS inhibitors impair cognitive function in the three panel runway and passive avoidance tasks in rats
Utkan, Tijen; Göçmez, Semil Selcen; Özer, Cüneyt; Gacar, Nejat; Arıcıoğlu, Feyza (Pergamon-Elsevier Science Ltd, 2012)The aim of this study was to compare the effects of both neuronal NOS (nNOS) and inducible NOS (iNOS) inhibitor 2-iminobiotin, with the more selective nNOS inhibitor N-omega-propyl-L-arginine (NPLA) and selective inducible ...