Yazar "Tozkır, Hilmi" için listeleme
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Breast, ovarian and other site cancer patients with BRCA 1/2 mutations: Data from Turkish multicenter retrospective study
Köstek, O.; Kücükarda, Ahmet; Tozkır, Hilmi; Nihat Okten, I.; Özden, E.; Çabuk, D.; Cicin, İrfan (Zerbinis Publications, 2021)Purpose: To demonstrate the clinical and demographic findings of the patients harboring BRCA1/2 mutations with breast, genital tract, prostate and pancreas cancers. Methods: The results of sequencing analysis of 200 cancer ... -
Clinical results of chromosome 15 copy number variations
Gürkan, H.; Atlı, E.; Yalçıntepe, S.; Atlı, E.; Demir, S.; Özen, Y.; Tozkır, Hilmi (Springernature, 2020)[No Abstract Available] -
Cytotoxic Antibody Detection by Means of Flow-Cytometric Cross-Match
Bilgen, Türker; Ata, P.; Tozkir, J.; Tozkır, Hilmi; Titiz, Mesut İzzet (Elsevier Science Inc, 2017)Background. Complement-dependent lymphocytotoxicity (CDC-XM) and flowcytometric (FCXM) cross-match are analyzed individually for each donor and recipient pair, because these techniques have fundamental differences for the ... -
Genetic screening results of individuals with high risk BRCA-related breast/ovarian cancer in Trakya region of Turkey
Demir, Selma; Tozkır, Hilmi; Gürkan, Hakan; Atli, E. Ikbal; Yalçıntepe, Sinem; Atli, Engin; Cicin, İrfan (Imprimatur Publications, 2020)Purpose: Pathogenic/likely pathogenic (P/LP) germline variations in BRCA1 and BRCA2 genes are responsible for the majority of hereditary breast and ovarian cancers. This study presents the BRCA1/BRCA2 sequencing and deletion ... -
Investigation of the Relationship Between Genome Wide Association Studies-derived Polymorphisms and Differentiated Thyroid Cancer Risk in a Turkish Population
Demir, Selma; Gürkan, Hakan; Çelik, Mehmet; Sezer, Atakan; Eker, Damla; Güldiken, Sibel; Palabiyik, Orkide; Tozkır, Hilmi (Gazi Univ, Fac Med, 2021)Background: Thyroid cancer is the most common malignancy of endocrine system. Genome Wide Association Studies (GWAS) revealed a number of common variants associated with thyroid cancer risk. In this study, we aimed to ... -
miR-320a promotes p53-dependent apoptosis of prostate cancer cells by negatively regulating TP73-AS1 in vitro
Bozgeyik, Esra; Arslan, Ahmet; Temiz, Ebru; Batar, Bahadır; Koyuncu, İsmail; Tozkır, Hilmi (Academic Press Inc Elsevier Science, 2022)TP73 antisense RNA 1 (TP73-AS1) is an oncogenic long non-coding RNA that is activated in several types of cancers. It has been shown that the activity of TP73-AS1 is controlled by several miRNAs, but post -transcriptional ... -
Next generation sequencing analysis of BRCA1 and BRCA2 identifies novel variations in breast cancer
Yıldız Tacar, Seher; Bozgeyik, Esra; Şeber, Erdoğan Selçuk; Yetişyiğit, Tarkan; Tozkır, Hilmi; Avcı, Okan; Arslan, Ahmet (Elsevier Inc., 2020)Mutations in two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified to be the most important predisposing factors for the development of breast cancer. Thus, BRCA1/2 testing is a well-established ... -
Next-generation screening of a panel of genes associated with periodic fever syndromes in patients with Familial Mediterranean Fever and their clinical characteristics
Bozgeyik, Esra; Mercan, Rıdvan; Arslan, A.; Tozkır, Hilmi (Academic Press Inc., 2020)Familial Mediterranean Fever (FMF) is a hereditary fever syndrome that primarily affects Mediterranean populations. For the study, total number of 182 patients with FMF disease were enrolled and screening of a panel of ... -
Silencing of TP73-AS1 impairs prostate cancer cell proliferation and induces apoptosis via regulation of TP73
Arslan, A.; Batar, Bahadır; Temiz, E.; Tozkır, Hilmi; Koyuncu, İsmail; Bozgeyik, Esra (Springer Science and Business Media B.V., 2022)Background: Prostate cancer is a malignant disease that severely affects the health and comfort of the male population. The long non-coding RNA TP73-AS1 has been shown to be involved in the malignant transformation of ... -
An unexpected clinical presentation in periodontal Ehler-Danlos syndrome: preterm birth, profound intellectual disability and self-injurious behavior
Baykal, Saliha; Yıldız, Tuğçe; Gürbüz, Gürkan; Tozkır, Hilmi (Lippincott Williams & Wilkins, 2023)[Abstract Not Available]