Yazar "Halıcı, Zekai" için listeleme
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Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats
Keskin, Halil; Tavacı, Taha; Halıcı, Hamza; Yüksel, Tuğba Nurcan; Özkaraca, Mustafa; Bilen, Arzu; Halıcı, Zekai (Wiley, 2022)Background A sepsis model was created, induced by cecal ligation and puncture (CLP), in juvenile rat groups. Milrinone (MIL), which is known to have a modulatory effect on pro-inflammatory cytokines, was administered to ... -
The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats
Köse, Duygu; Yüksel, Tuğba Nurcan; Halıcı, Zekai; Çadırcı, Elif; Gürbüz, Muhammed Ali (Aves, 2021)Objective: We designed an experimental model of sepsis in rats to investigate the effects of agomelatine (AGO) on lung tissues using molecular and histopathological methods. Materials and Methods: In our experimental model, ... -
Neuroprotective effect of roflumilast under cerebral ischaemia/reperfusion injury in juvenile rats through NLRP-mediated inflammatory response inhibition
Keskin, Halil; Keskin, Filiz; Tavaci, Taha; Halıcı, Hamza; Yüksel, Tuğba Nurcan; Özkaraca, Mustafa; Halıcı, Zekai (Wiley, 2021)This study aims to investigate the protective effect of roflumilast, a phosphodiesterase (PDE)-4 enzyme inhibitor, and demonstrate its possible role in the development prevention of cerebral ischemia/reperfusion injury ... -
Protective effect of 5-HT7 receptor activation against glutamate-induced neurotoxicity in human neuroblastoma SH-SY5Y cells via antioxidative and antiapoptotic pathways
Yüksel, Tuğba Nurcan; Yayla, Muhammed; Halıcı, Zekai; Çadırcı, Elif; Polat, Beyzagül; Köse, Duygu (Pergamon-Elsevier Science Ltd, 2019)Serotonin exerts anti-inflammatory, antioxidant and antiapoptotic effects through 5-HT7 receptors. The present study determined the role of 5-HT7 receptors in glutamate-induced neurotoxicity by using human SH-SY5Y neuroblastoma ... -
Protective effects of melatonin receptor agonists on endotoxin- induced uveitis in rats
Yüksel, Tuğba Nurcan; Yayla, Muhammed; Köşe, Duygu; Halıcı, Zekai; Bozkurt, Erdinç; Toktay, Erdem (Mashhad Univ Med Sciences, 2023)Objective(s): Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis ...