Ucar, OkanOzturk, Ibrahim I.Grzeskiewicz, Anita M.Kubicki, MaciejBanti, ChristinaHadjikakou, Sotiris K.2025-04-062025-04-0620250020-16931873-3255https://doi.org/10.1016/j.ica.2025.122627https://hdl.handle.net/20.500.11776/17237The synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes containing thiophene-derived ligands are reported. Two complexes were synthesized: {[SbBr2(kappa 2-N3, S-Hatetsc)]} (1) and {[SbCl2(eta 1-S-Hatmtsc)(kappa 2-N3,S-Hatmtsc)]} (2). X-ray crystallography revealed complex 1 adopts a distorted seesaw structure, while complex 2 has a distorted square pyramidal structure. Both complexes showed significant antiproliferative activity against HeLa cancer cells. They also exhibited enhanced antibacterial activity against Gram-negative bacteria, particularly Escherichia coli. This study highlights the potential of thiophene-based antimony(III) complexes as promising candidates for anticancer and antibacterial therapies.en10.1016/j.ica.2025.122627info:eu-repo/semantics/closedAccessacetylthiophene thiosemicarbazoneAnticancer activityAntimicrobial activityAntimony(III)Crystal structureArticle581Q2WOS:0014441494000012-s2.0-86000368099Q2