Çakmak, MehmetÖztürk, İbrahim İsmetBanti, Christina N.Manoli, MariaMoushi, E.Tasiopoulos, Anastasios J.Hadjikakou, Sotiris K.2022-05-112022-05-1120180792-12412191-0219https://doi.org/10.1515/mgmc-2018-0035https://hdl.handle.net/20.500.11776/7260New bismuth(III) bromine compounds of the heterocyclic thioamides were prepared and structurally characterized. The reaction of heterocyclic thioamides with bismuth(III) bromide resulted in the formation of the {[BiBr2(mu(2)-Br)(MMI)(2)](2)center dot CH3COCH3 center dot H2O} (1), {[BiBr2(MBZIM)(4)]center dot Br center dot 2H(2)O} (2), {[BiBr2(mu(2)-Br)(tHPMT)(2)](2)center dot CH3CN} (3), {[BiBr2(mu(2)-Br)(PYT)(2)](2)center dot CH3CN} (4) and {[BiBr2(mu(2)-Br)(MBZT)(2)](2) 2CH(3)OH} (5) complexes (MMI: 2-mercapto-1-methylimidazole, MBZIM: 2-mercaptobenzimidazole, tHPMT: 2-mercapto-3,4,5,6-tetrahydro-pyrimidine, PYT: 2-mercaptopyridine and MBZT: 2-mercaptobenzothiazole). The complexes 1-5 were characterized by melting point (m.p.), elemental analysis (c.a.), molar conductivity, Fourier-transform infrared (FT-IR), Fourier-transform Raman (FT-Raman), nuclear magnetic resonance (H-1 and (CNMR)-C-13) spectroscopy, UV-Vis spectroscopy and thermogravimetric-differential thermal analysis (TG-DTA). The molecular structures of 1-5 were determined by single-crystal X-ray diffraction. Complex 2 is a first ionic monomuclear octahedral bismuth(III) bromide, while the complexes 1,3-5 are the first examples of dinuclear bismuth(III) bromide derivatives. Complexes 1-5 were evaluated in terms of their in vitro cytotoxic activity against human adenocarcinoma breast (MCF-7) and cervix (HeLa) cells. The toxicity on normal human fetal lung fibroblast cells (MRC-5) was also evaluated. Moreover, the complexes 1-5 and free heterocyclic thioamide ligands were studied upon the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX).en10.1515/mgmc-2018-0035info:eu-repo/semantics/openAccessbiological inorganic chemistrybismuth(III) bromidecytotoxicitythioamidesAntimony(Iii) Halide-ComplexesHuman Breast-CancerStructural-CharacterizationCrystal-StructureIn-VitroBiological-ActivityChloride ComplexesX-RayThioureaCatalystsArticle4145448143154Q4WOS:0004510036000022-s2.0-85054411302Q3