Şahin, AyhanBaran, Onur2022-05-112022-05-1120220300-06051473-2300https://doi.org/10.1177/03000605221086737https://hdl.handle.net/20.500.11776/4826Objective Erector spinae plane (ESP) block is an alternative to neuraxial block for post-surgical pain in nephrectomy patients. However, no clinical trial has directly compared ESP block with a control group. Methods In a single-center, double-blind randomized comparative trial, patients undergoing nephrectomy with a subcostal flank incision under general anesthesia were divided into the following two groups: ESP block group (ESP block before anesthesia) and non-ESP (control) group (no intervention). The primary outcome measure was pain score (Numeric Rating Scale [NRS] 0 to 10). Secondary outcomes were postoperative opiate use, anesthetic and surgical complications, length of hospital stay, and patient-reported outcomes. Results Postoperatively (0 to 24 hours), the ESP block group experienced less pain and had lower NRS pain scores 0 to 24 hours postoperatively than the non-ESP group. Opioid consumption and the number of rescue analgesic doses decreased significantly in the ESP group compared with the non-ESP group. Patient-Reported Outcomes Information System (Quality of Recovery-15) scores significantly improved in the ESP group compared with the non-ESP block group. Conclusions Patients receiving an ESP block for intraoperative and postoperative analgesia during radical nephrectomies experienced less postoperative pain 0 to 24 hours compared with the non-ESP group.en10.1177/03000605221086737info:eu-repo/semantics/openAccessRegional anesthesiaultrasound guidanceerector spinae plane blocknephrectomypostoperative painopioid consumptionPostoperative AnalgesiaMajor ComplicationsEpidural AnalgesiaEsp BlockManagementArticle503Q4WOS:00077269400000135301896