Güzel, SavaşCinemre, Fatma Behice SerinkanGüzel, Eda ÇelikKüçükyalçın, VolkanKızıler, Ali RızaÇavuşoğlu, CoşkunAydemir, Birsen2022-05-112022-05-1120181119-3077https://doi.org/10.4103/njcp.njcp_309_17https://hdl.handle.net/20.500.11776/5604Background and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B 12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 +/- 6.8 ng/mL vs. 18.39 +/- 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 +/- 34.06 mu g/dL and 172.55 +/- 45.47 mu g/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B 12 levels (r = -0.298, P < 0.023, r = -0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.en10.4103/njcp.njcp_309_17info:eu-repo/semantics/closedAccessAtherosclerosischolesterolhypertensionmidkineBinding Growth-FactorExperimental Autoimmune EncephalomyelitisZinc-DeficiencyBiological-ActivitiesDiabetic-NephropathyKidney-DiseasesInflammationPleiotrophinPathogenesisAngiotensinArticle217894900Q4WOS:0004390470000132-s2.0-8505010798729984722Q3