Aydın, MuratYılmaz, AhsenDonma, Mustafa MetinTülübaş, FetiDemirkol, MuhammedErdoğan, MuratGürel, Ahmet2022-05-112022-05-1120152148-4902https://doi.org/10.14744/nci.2015.25238https://hdl.handle.net/20.500.11776/5610OBJECTIVE: Obesity is a growing health problem in most of the developed countries. It is associated with many chronic diseases, affecting particularly endocrine and cardiovascular systems. Inflammation plays a key role in pathophysiology of obesity. In this study, we aimed to investigate the inflammation status in obese children using neutrophil/lymphocyte ratio. METHODS: In this study 130 obese and 57 healthy children were assessed retrospectively. According to Centers for Disease Control 2000 (CDC) BMI percentiles for childhood and adulthood, 85-95 percentile was considered as overweight and >95 percentile as obese. RESULTS: Lymphocyte/neutrophil ratios in the obese group were significantly higher compared to those in healthy controls (p = 0.03 and p = 0.045, respectively). Neutrophil/lymphocyte ratio and CRP level in the obese group were significantly higher compared to those in healthy controls (p = 0.02 and p = 0.00, respectively). Thrombocyte/lymphocyte ratios were not significantly different between two groups (p = 0.156). CONCLUSION: It is possible that childhood obesity which has been increasingly prevalent recently triggers the pathogenesis of atherosclerosis during the early years of life. Increased neutrophil/lymphocyte ratio might be associated with the severity of inflammation which plays a role in the early stages of atherosclerosis. Therefore, taking childhood obesity under control using diet and other treatment methods will prevent mortality and morbidity in the elderly.en10.14744/nci.2015.25238info:eu-repo/semantics/openAccessChildhood obesityinflammationneutrophil/lymphocyte ratioNeutrophil-Lymphocyte RatioMean Platelet VolumeCardiovascular-DiseaseInsulin-ResistanceAdipose-TissueAssociationOverweightChildrenAtherosclerosisYoungArticle228791N/AWOS:00043992170000128058347