Demirkiran, A.Aydin, C.Yilmaz, A.Celikkol, A.Alpsoy, S.Donbaloglu, O.Topcu, B.2024-10-292024-10-2920231128-3602https://hdl.handle.net/20.500.11776/14980OBJECTIVE: Multimerin-2 is an adhesion substrate between pericytes and basal membranes during angiogenesis. The present study aimed to assess the relationship between serum Multimerin-2 and coronary collateral flow grade. PATIENTS AND METHODS: Between April 2022 and August 2022, 88 patients with subacute ST-elevation myocardial infarction were included in this study. The main inclusion criteria were patients who present 12-48 hours after symptom onset and aged between 18 and 90 years. The patients were divided into two groups according to the Rentrop classification: poor collateral group (Rentrop grade 0-1) and good collateral group (Rentrop grade 2-3). Biochemical and hematological parameters were measured before coronary angiography. RESULTS: Serum Multimerin-2 levels were found to be significantly different between the two groups, and levels were higher in the Rentrop 2-3 group than in the Rentrop 0-1 group (3,527.9 +/- 1,194.2 pg/ml and 946.7 +/- 249.1 pg/ml; p < 0.00). Receiver operating characteristic curve analysis indicated that the area under the curve was 0.918 ( p = 0.001), and the best cut-off value of 849 pg/ ml had a sensitivity of 90.1% and a specificity of 84.1% for predicting Rentrop grade 2- 3 coronary flow. The number of patients with low left ventricular ejection fraction ( LVEF) by echocardiography at 30 days was significantly higher in patients with poor collateralization. CONCLUSIONS: Multimerin-2 levels were found to be higher in patients with Rentrop grade 2-3 coronary flow than Rentrop grade 0-1 coronary flow after myocardial infarction. We detected a potential relationship between MMR-2 and good coronary collateral formation.eninfo:eu-repo/semantics/closedAccessMultimerin-2Coronary collateral flow gradeMyocardial infarctionRentrop classificationArticle271362566263N/AWOS:00104515930000137458637