Türk, YaşarKüskün, AtakanDevecioğlu, İsmail2022-05-112022-05-1120200174-15511432-086Xhttps://doi.org/10.1007/s00270-020-02585-4https://hdl.handle.net/20.500.11776/5415Purpose To evaluate the rate of iatrogenic pneumothorax and the need for intervention with extrapleural autologous blood injection (EPABI) along with intraparenchymal autologous blood patch injection (IABPI) or IABPI-only in CT-guided percutaneous lung biopsy. Materials and Methods One hundred and thirty-nine participants were referred for CT-guided percutaneous lung biopsy, and 81 were randomized into study (EPABI + IABPI,n = 40) and control (IABPI-only,n = 41) groups. In the study group, similar to 5 ml of autologous blood was injected into the extrapleural space before passing through the parietal and visceral pleura. The primary outcome was the incidence of pneumothorax in two cohorts within 2 weeks after the procedure. Results In the per-protocol population, pneumothorax rates were 5.9% and 25.7% in the study and control groups, respectively. The difference between the two groups was -19.8% (95% CI: -36.3%, 3.32%) (p = 0.025). On the other hand, in the population with no intraprocedural deviations, pneumothorax rates were 3.2% and 17.2% in the study and control groups, respectively. The difference between the two groups was -14.0% (95% CI: -29.1%, 1.07%) (p = 0.083). In the control group, 3.45% of the cases required aspiration, while no intervention was required in the study group. Conclusion The EPABI application along with IABPI is a promising method to decrease the incidence of pneumothorax following CT-guided percutaneous lung biopsy.en10.1007/s00270-020-02585-4info:eu-repo/semantics/closedAccessIatrogenic pneumothoraxIntraparenchymal autologous blood patch injectionExtrapleural spaceExtrapleural autologous blood injectionCT-guidedPercutaneous lung biopsyChest Tube PlacementNeedle-AspirationPneumothoraxPreventionManagementTrackRatesArticle43913151322Q3WOS:0005493371000052-s2.0-8508797315832676959Q2