Aygün, ÖzlemGrzeskiewicz, Anita M.Banti, Christina N.Hadjikakou, Sotiris K.Kubicki, MaciejÖztürk, İbrahim İsmet2023-04-202023-04-2020220277-53871873-3719https://doi.org/10.1016/j.poly.2022.115683https://hdl.handle.net/20.500.11776/11007Due to their chemical and biological properties, the interest in thiosemicarbazones and their metal complexes is increasing day by day. In this study, the effect of the substituents at the N-1 atoms of the thiosemicarbazones and the effect of halogen atoms on the type and biological properties of bismuth(III) complexes is investigated. The reactions of bismuth(III) halide with a series of benzaldehyde-N-1-alkyl-thiosemicarbazones in 1:3 M ratio yield bismuth(III) halide complexes: {BiBr3(eta(1)-S-Hbztsc)3} (1), {BiCl3(eta(1)-S-Hbzmtsc)(3)} (2), {BiBr3(eta(1)-S-Hbzmtsc)(3)} (3), {[BiCl3(eta(1)-S-Hbzetsc)(3)].CH3OH} (4) and {BiBr3(eta(1)-S-Hbzetsc)(3)} (5). Complexes 1-5 were characterized by a number of different spectroscopic methods. The crystal structures of complexes 1-5 and the free ligand benzaldehyde-N-methyl-thiosemicarbazone were determined by X-ray diffraction. Complexes 1-5 were tested for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) cell line. Complexes 1-5 showed low cytotoxic activity. The antibacterial activities of 1-5 and their free ligands against four strains bacteria of Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli have been examined. The results indicated that bismuth(III) complexes 1-5 are most active against E. coli and, among them, complex 4 exhibits the highest activity. Lipoxygenase (LOX) inhibitory activity of the bismuth(III) halide complexes 1-5 and the free ligands has been detected experimentally. The IC50 values indicate that bismuth(III) halide complexes 1-5 have a higher enzyme inhibition potential than free ligands and cisplatin.en10.1016/j.poly.2022.115683info:eu-repo/semantics/closedAccessBismuth(Iii) ComplexThiosemicarbazoneSpectroscopyCrystal StructureBiological ActivityChloride ComplexesCrystal-StructuresPrecursorsLigandsArticle215Q2WOS:0007794118000042-s2.0-85123621103Q2