Gerçek, ZuhalCeyhan, DenizErçağ, Erol2022-05-112022-05-1120211300-0527https://doi.org/10.3906/kim-2012-25https://hdl.handle.net/20.500.11776/4706In 2020, the world tried to combat the corona virus (COVID-19) pandemic. A proven treatment method specific to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is still not found. In this study, seven new antiviral compounds were designed for COVID-19 treatment. The ability of these compounds to inhibit COVID-19's RNA processing was calculated by the molecular docking study. It has been observed that the compounds can have high binding affinities especially against NSP12 (between -9.06 and -8.00 kcal/mol). The molecular dynamics simulation of NSP12-ZG 7 complex proved the stability of interaction. The synthesis of two most active molecules was performed by one-pot reaction and characterized by FT-IR, H-1-NMR, C-13-NMR, and mass spectroscopy. The compounds presented with their synthesis are inhibitory core structures against SARS-CoV-2 infection.en10.3906/kim-2012-25info:eu-repo/semantics/openAccessCOVID-19SARS-CoV-2molecular docking studyantiviral drugForce FieldArticle453704718Q4WOS:00066836580001734385863