Surov, A.Thormann, M.Kardaş, H.Hinnerichs, M.Omari, J.Cingöz, E.Cingöz, M.Chousein, O.Sasani, HadiGönen, Korcan Aysun2023-05-062023-05-0620230007-1285https://doi.org/10.1259/bjr.20220869https://hdl.handle.net/20.500.11776/12169Objective: To evaluate the association of body composition parameters with outcomes in Covid-19. Methods: 173 patients hospitalized for Covid-19 infection in 6 European centers were included in this retrospective study. Measurements were performed at L3-level and comprised skeletal muscle index (SMI), muscle density (MD), and adipose tissue measurements [visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), intramuscular adipose tissue (IMAT), visceral-to-subcutaneous-adipose-tissue-area-ratio (VSR)]. The association with mortality, the need for intubation (MV), and the need for admission to ICU within 30 days were evaluated. Results: Higher SAT density was associated with a greater risk of MV (OR = 1.071, 95%CI=(1.034;1.110), p < 0.001). Higher VAT density was associated with admission to ICU (OR = 1.068, 95%CI=(1.029;1.109), p < 0.001). Higher MD was a protective factor for MV and ICU admission (OR = 0.914, 95%CI=(0.870;0.960), p < 0.001; OR = 0.882, 95%CI=(0.832;0.934), p = 0.028). Higher VSR was associated with mortality (OR = 2.147, 95%CI=(1.022;4.512), p = 0.044). Male sex showed the strongest influence on the risk of ICU admission and MV. SMI was not associated with either parameter. Conclusion: In patients hospitalized for Covid-19 infection, higher VSR seems to be a strong prognostic factor of short-term mortality. Weak associations with clinical course were found for MD and adipose tissue measurements. Male sex was the strongest prognostic factor of adverse clinical course. Advances in knowledge: VSR is a prognostic biomarker for 30-day mortality in patients hospitalized for Covid-19 disease. © 2023 The Authors.en10.1259/bjr.20220869info:eu-repo/semantics/closedAccessadipose tissueadolescentadultagedanthropometric parametersArticlebody compositionbody composition parameterscomputer assisted tomographycontrolled studycoronavirus disease 2019femalehospital admissionhospital patienthumanintensive care unitintra-abdominal fatintramuscular fatintubationlumbar spinemajor clinical studymalemeasurementmortalitymulticenter studymuscle masspandemicpredictionprognosisretrospective studyrisksex differenceskeletal musclesubcutaneous fatvisceral to subcutaneous adipose tissue ratioclinical trialdiagnostic imagingdisease exacerbationintra-abdominal fatsubcutaneous fatAdipose TissueCOVID-19Disease ProgressionHumansIntra-Abdominal FatMaleRetrospective StudiesSubcutaneous FatArticle961144Q3WOS:0009834001000092-s2.0-8515075115336744766Q2