Erdem, İlknurHakan, TayfunCeran, NurgülMetin, FatmaAkçay, Seniha ŞenbayrakKüçükercan, MetinGöktaş, Paşa2022-05-112022-05-1120080028-38861998-4022https://doi.org/10.4103/0028-3886.44629https://hdl.handle.net/20.500.11776/8663Background: Nosocomial meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. Aim: The aim of this study was to describe the clinical characteristics and the risk factors associated with mortality in patients who developed nosocomial meningitis following neurosurgical operations. Setting and design: Tertiary care hospital and an observational study. Materials and Methods: The study subjects included 2265 patients who underwent various neurosurgical operations during 2003-05. The diagnosis of nosocomial meningitis was based on the Center for Disease Control criteria. Statistical analysis: It was performed by using Statistical Package for Social Sciences for Windows 10.0 program. Results: The incidence of postoperative nosocomial meningitis was 2.7% (62 episodes in 49 patients among 2265 patients operated). Staphylococcus aureus and Acinetobacter spp. were the most frequently isolated pathogens. Of the 49 with meningitis 20 (40.8%) patients died. In the logistic regression analysis model, Glascow coma scale score less than 10 (Odds Ratio (OR): 19.419, 95% Confidence Interval (CI); 1.637-230.41, P = 0.001), and low cerebrospinal fluid glucose level (= 30 mg/dL) (OR: 10.272, 95% CI; 1.273-82.854, P= 0.002), and presence of concurrent nosocomial infection (OR: 28.744, 95% CI; 1.647-501.73, P= 0.001) were the independent risk factors associated with mortality. Conclusion: The mortality in patients who developed meningitis was high. The high percentage of concurrent nosocomial infections was associated with a high mortality rate which was a serious problem.en10.4103/0028-3886.44629info:eu-repo/semantics/openAccessMeningitismortalityneurosurgerynosocomialpostoperativeNosocomial Bacterial-MeningitisSite InfectionsAdultsNeurosurgeryMulticenterCraniotomyArticle564433437Q4WOS:0002626561000072-s2.0-5874911307119127038Q3