Gönen, TansuGüzel, SavaşKeskinbora, Kadircan Hıdır2022-05-112022-05-1120190950-222Xhttps://doi.org/10.1038/s41433-018-0308-8https://hdl.handle.net/20.500.11776/4832Purpose: To investigate the YKL-40, as a marker of inflammation, in aqueous humor and serum of cataract patients with and without pseudoexfoliation syndrome (PEX). Methods: Aqueous humor and serum samples were obtained from 44 patients who underwent phacoemulsification surgery. All patients were divided into two groups: PEX (n = 24) and control (n = 20). YKL-40 levels were measured with enzyme-linked immunosorbent assay (ELISA). The differences between the groups were assessed by using Chi-square and independent sample t-tests. The Pearson correlation coefficient was used to evaluate the correlation between variables. Results: There was a significant difference between the mean YKL-40 levels in the aqueous humor of PEX group (112.0 ± 35.8 ng/mL) and control subjects (88.2 ± 30.6 ng/mL) (P = 0.025). However, the difference between the mean YKL-40 levels in the serum of PEX group (53.5 ± 29.1 ng/mL) and control subjects (44.6 ± 30.2 ng/mL) was non-significant (P = 0.326). The correlation between aqueous humor and serum YKL-40 concentrations was significant in both the groups (r = 0.833, P < 0.001; r = 0.840, P < 0.001, respectively). Conclusions: Increased aqueous humor levels of YKL-40 demonstrate that it is local, but not a systemic marker for inflammation in patients with PEX. © 2018, The Royal College of Ophthalmologists.en10.1038/s41433-018-0308-8info:eu-repo/semantics/openAccessbiological markerchitinase 3 like protein 1tropicamidebiological markerCHI3L1 protein, humanchitinase 3 like protein 1growth promotoragedanterior lens capsuleaqueous humorArticleblood samplingcase control studycataractclinical articlecollegecontrolled studycorrelation coefficientenzyme linked immunosorbent assayeye examinationfemalegonioscopyhumaninflammationintraocular pressurelaboratory testmaleophthalmoscopyphacoemulsificationprospective studyprotein blood levelpseudoexfoliationsenile cataractserumslit lamp microscopytonometrybloodinflammationmetabolismpseudoexfoliationvery elderlyAgedAged, 80 and overAqueous HumorBiomarkersCase-Control StudiesCataractChitinase-3-Like Protein 1Enzyme-Linked Immunosorbent AssayExfoliation SyndromeFemaleGrowth SubstancesHumansInflammationMalePhacoemulsificationProspective StudiesArticle335772776Q2WOS:0004672293000132-s2.0-8505878615230560917Q1