Uludağ, Nesimi2022-05-112022-05-1120201857-5552https://doi.org/10.20450/mjcce.2020.1736https://hdl.handle.net/20.500.11776/4685new synthetic route for the (±)-nordasycarpidone was achieved in five steps with an overall yield of 41 %. This route involves ring closure and formation of 5 which has a methanoazocino[4,3-b]indole skeleton in the key step. The reaction also involved a cyclization reaction of tetrahydrocarbazole with a monoalkyl nitrile side chain at the C-2 position, and this reaction was mediated by tetrachloro-1,4-benzoquinone (TCB). The central step in the synthesis was the closure of the D-ring of the intra-molecu-lar structure and the addition of amine, which resulted in an aza-tetracyclic substructure that contained the ABCD-ring of the strychnos alkaloid family. © 2020, Macedonian Journal of Chemistry and Chemical Engineering.en10.20450/mjcce.2020.1736info:eu-repo/semantics/openAccess1,5-methanoazacino[4,3-b]indoleDasycarpidoneNordasycarpidoneUleineArticle3911116Q4WOS:0005379423000032-s2.0-85086520093Q4