Akyüz, AydınAydın, FatmaAlpsoy, ŞerefÖzkaramanlı Gür, DemetGüzel, Savaş2022-05-112022-05-1120192149-22632149-2271https://doi.org/10.14744/AnatolJCardiol.2019.43247https://hdl.handle.net/20.500.11776/5324Objective: The pathophysiology of coronary slow flow (CSF) has not been clarified. Salusin-beta is released predominantly from the atheroma plaques and influences the pathophysiologic processes of atherosclerosis. Therefore, this study aimed to determine serum salusin-beta levels in CSF and its correlation with CSF. Methods: The study included 39 patients with CSF, and the control group (n=42) consisted of consecutive subjects with normal coronary arteriogram. We measured salusin-beta and thrombolysis in myocardial infarction frame count (TFC). Results: Age, body mass index (BMI), systolic blood pressure, diabetes, hyperlipidemia, and smoking rates were similar (p values>0.05) in both groups. High sensitive C-reactive protein (2.80 +/- 1.2 vs. 2.21 +/- 1.2 mg/dL, p=0.011), salusin-beta [1205 (330-2092) vs. 162 (29-676), pg/ml, p<0.001], corrected TFC of left anterior descending coronary artery (29 +/- 9 vs. 19.7 +/- 3.7, p<0.001), circumflex artery TFC (25 +/- 10 vs. 15 +/- 3.2, p<0.001), right coronary artery TFC (28 +/- 7.1 vs. 13 +/- 3.3, p<0.001), and mean TFC (28 +/- 4.4 vs. 16 +/- 3.7, p<0.001) were significantly higher in the CSF group. In univariate and multivariate regression analysis, only BMI (unstandardized beta +/- SE=0.178 +/- 0.08, p=0.036) and salusin-beta levels (unstandardized beta +/- SE=0.006 +/- 0.01, p<0.001) were determined as predictors of CSF. There was a good correlation between serum salusin-beta and mean TFC values (r=0.564; p<0.001). Conclusion: There is an association between serum salusin-beta levels and CSF.en10.14744/AnatolJCardiol.2019.43247info:eu-repo/semantics/openAccessatherosclerosiscoronary slow flowsalusin-betaendothelial dysfunctionIntima-Media ThicknessC-Reactive ProteinNf-Kappa-BEndothelial DysfunctionIntravascular UltrasoundIn-VivoAtherosclerosisInflammationArteriesLesionsArticle224177184Q4WOS:0004882864000072-s2.0-8507293251131584433Q3