Özcan Gökçek, EmelIşık, Raziye2022-05-112022-05-1120200920-1742https://doi.org/10.1007/s10695-020-00779-8https://hdl.handle.net/20.500.11776/5001The IGF-I is a significant peptide hormone to cell growth, development, reproduction, and metabolism of teleost fish. This study was conducted to investigate the IGF-I gene polymorphism and to reveal the association between the genotypes of IGF-I gene and growth traits in 80 harvest size European sea bass (Dicentrarchus labrax, L.) reared in İzmir region of Turkey. The 821 bp long exon 1 and 5’ UTR regions of IGF-I gene were amplified, and PCR products were analyzed via DNA sequencing method. Two novel single nucleotide polymorphisms (SNPs) such as g.46672A > G and g.46749C > T in the 5’ UTR region of IGF-I gene in the European sea bass were detected for the first time with this study. Associations between the genotypes of IGF-I g.46749C > T locus and body weight were found statistically significant (p < 0.05). The genotypes of IGF-I g.46749C > T and g.46672A > G loci were found significantly associated with total length (p < 0.05). However, both loci did not show significant associations with body width. The studied gene region sequences were entered to NCBI GenBank database with the accession numbers: MK621680-MK621682. Thus, these polymorphisms have a significant effect on the body weight and total length which could be useful for sea bass selection and breeding for marker-assisted selection (MAS) program. © 2020, Springer Nature B.V.en10.1007/s10695-020-00779-8info:eu-repo/semantics/closedAccessDNA sequencingEuropean sea bassIGF-I genePolymorphismfish proteinsomatomedin CanimalbassDNA sequencegeneticsgenotypegrowth, development and agingmalesingle nucleotide polymorphismturkey (bird)AnimalsBassFish ProteinsGenotypeInsulin-Like Growth Factor IMalePolymorphism, Single NucleotideSequence Analysis, DNATurkeyArticle46311311138Q2WOS:0005184254000012-s2.0-8508160985732140978Q1