Gürdal, Sibel ÖzkanÖzaydın, Ayşe NilüferArıbal, ErkinÖzçınar, BeyzaCabıoğlu, NeslihanŞahin, CennetÖzmen, Vahit2022-05-112022-05-1120211305-3612https://doi.org/10.5152/dir.2021.20486https://hdl.handle.net/20.500.11776/8168PURPOSE We aimed to show the effects of long-term screening on clinical, pathologic, and survival outcomes in patients with screen-detected breast cancer and compare these findings with breast cancer patients registered in the National Breast Cancer Registry Data (NBCRD). METHODS Women aged 40-69 years, living in Bahcesehir county, Istanbul, Turkey, were screened every 2 years using bilateral mammography. The Bahcesehir National Breast Cancer Registry Data (BMSP) data were collected during a 10-year screening period (five rounds of screening). BMSP data were compared with the NBCRD regarding age, cancer stage, types of surgery, tumor size, lymph node status, molecular subtypes, and survival rates. RESULTS During the 10-year screening period, 8758 women were screened with 22621 mammograms. Breast cancer was detected in 130 patients; 51 (39.2%) were aged 40-49 years. The comparison of breast cancer patients in the two programs revealed that BMSP patients had earlier stages, higher breast-conserving surgery rates, smaller tumor size, more frequent negative axillary nodal status, lower histologic grade, and higher ductal carcinoma in situ rates than NBCRD patients (p = 0.001, for all). CONCLUSION These results indicate the feasibility of successful population-based screening in middle-income countries.en10.5152/dir.2021.20486info:eu-repo/semantics/openAccessPrognostic-FactorsMammographyWomenTrialReductionTurkeyArticle272157163Q3WOS:0006290397000012-s2.0-8510296395433599208Q2