Tülübaş, FetiOran, MustafaMete, RafetTuran, FilizYılmaz, AhsenYıldız, Zeynep DenizGürel, Ahmet2022-05-112022-05-1120141300-01441303-6165https://doi.org/10.3906/sag-1302-90https://hdl.handle.net/20.500.11776/5236Aim: Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups. Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.en10.3906/sag-1302-90info:eu-repo/semantics/openAccessIrritable bowel syndromemacrophage migration inhibitory factormonocyte chemotactic proteininflammationDendritic CellsUlcerative-ColitisCytokineExpressionResponsesMifAngiogenesisGrowthArticle446967971Q4WOS:0003441559000092-s2.0-8490806632625552148Q3