Uludağ, Nesimi2022-05-112022-05-1120210009-31301573-8388https://doi.org/10.1007/s10600-021-03394-yhttps://hdl.handle.net/20.500.11776/7312A facile total synthesis of tubifolidine has been developed, which is accomplished in an 11-step synthesis of the ABCDE pentacyclic of the strychnos alkaloids with an overall yield of 10%. The key steps are the cyclization reaction for starting tetrahydrocarbazoles bearing a nitrilealkyl side chain at the C-2 position, mediated by tetrachloro-1,4-benzoquinone (TCB) and the intramolecular addition of the amide as the nucleophile. This cyclization reaction was obtained with the relevant architecture, including strychnos skeletal-type alkaloids.en10.1007/s10600-021-03394-yinfo:eu-repo/semantics/closedAccessindoletubifolidinestrychnos alkaloidsazocino[43-b]indoleConcise Total-SynthesisFt-IrFrameworkEntryRouteCoreMepNmrNloNboArticle573491496Q4WOS:0006555453000042-s2.0-85106686449Q3