Yılmazer, NadimCoşkun, CihanGürel Gürevin, EbruYaylım, İlhanEraltan, Ethem Hakanİkitimur Armutak, Elif İlkay2022-05-112022-05-1120161505-17732300-2557https://doi.org/10.1515/pjvs-2016-0074https://hdl.handle.net/20.500.11776/6868This study aimed to investigate antioxidant and anti-inflammatory activities of a commercial product of noni (Morinda citrifolia) juice. Carrageenan-induced rat paw edema was employed as inflammatory model. One control and three experimental groups were formed. Experimental groups were administered noni juice alone, noni juice+carrageenan, and carrageenan alone. Oxidant and antioxidant capacity were determined by d-ROMs test and BAP test, respectively. Plasma concentrations of endothelin-1 and leptin were measured by ELISA. Measurements were performed at zero time and 2nd hour of inflammation. Oxidant capacity decreased in noni-received groups at 2nd hour (p=0.019). Antioxidant capacity of the group which received noni alone was found to be higher at 2nd hour (p=0.036). Plasma concentrations of endothelin-1 and leptin were notably lower in noni-received groups (p=0.001 and p=0.021, respectively). The results show that the commercial noni juice investigated has pronounced antioxidant and anti-inflammatory activities.en10.1515/pjvs-2016-0074info:eu-repo/semantics/openAccesscarrageenannoni (Morinda citrifolia)anti-inflammatoryantioxidantMorinda-Citrifolia L.Chemical-ConstituentsOxidative StressPlasmaFruitInflammationExtractDogsArticle193589595Q3WOS:00038352840001827760029