Kandemir, HakanMa, CongKutty, Samuel K.Black, David StC.Griffith, RenateLewis, Peter J.Kumar, Naresh2022-05-112022-05-1120140968-08961464-3391https://doi.org/10.1016/j.bmc.2014.01.025https://hdl.handle.net/20.500.11776/7179A range of novel hydrazine bridged bis-indoles was prepared from readily available indole-7-glyoxyloylchlorides and 7-trichloroacetylindoles and underwent cyclodehydration to produce 2,5-di(7-indolyl)-1,3,4-oxadiazoles and a 2,2'-bi-1,3,4-oxadiazolyl with phosphoryl chloride in ethyl acetate. This efficient protocol was subsequently used for the synthesis of 2-and 7-indolyl 2-(1,3,4-thiadiazolyl) ketones from related indolyl-hydrazine carbothioamides. The synthesised bis-indoles were evaluated for their antimicrobial properties, particularly the inhibition of protein-protein complex formation between RNA polymerase andrfactor and their bactericidal effect on Gram positive Bacillus subtilis and Gram negative Escherichia coli. (C) 2014 Elsevier Ltd. All rights reserved.en10.1016/j.bmc.2014.01.025info:eu-repo/semantics/closedAccessBis-indolesOxadiazolesThiadiazolesIndole hydrazidesAntimicrobialRNA polymerase1,3,4-OxadiazolesAgents4,6-DimethoxyindolesMildArticle22516721679Q2WOS:0003317295000172-s2.0-8489669970724525002Q2